Heterofunctionalized Cavitands by Macrocyclization of Sequence-Defined Foldamers

Joseph W. Meisel, Chunhua T. Hu, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review


Macrocyclic hosts have long been the workhorses of molecular recognition. Despite the widespread use of container-shaped molecules as synthetic receptors, an efficient preparation of cavitands bearing multiple functional groups has not been realized. This Letter describes a new cavitand derived from a sequence-defined oligoamide foldamer scaffold. A solid-phase synthesis approach is reported, which enables the display of multiple chemically diverse functional groups on the cavitand rim.

Original languageEnglish (US)
Pages (from-to)7763-7767
Number of pages5
JournalOrganic Letters
Issue number19
StatePublished - Oct 4 2019

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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