TY - JOUR
T1 - Heterogeneity in immune responses
T2 - From populations to single cells
AU - Satija, Rahul
AU - Shalek, Alex K.
N1 - Funding Information:
We would like to thank members of the Regev and Hacohen groups for insightful discussions. R.S. is supported by National Institutes of Health (NIH) Postdoctoral Fellowship (1F32HD075541-01).
PY - 2014/5
Y1 - 2014/5
N2 - The mammalian immune system is tasked with protecting the host against a broad range of threats. Understanding how immune populations leverage cellular diversity to achieve this breadth and flexibility, particularly during dynamic processes such as differentiation and antigenic response, is a core challenge that is well suited for single cell analysis. Recent years have witnessed transformative and intersecting advances in nanofabrication and genomics that enable deep profiling of individual cells, affording exciting opportunities to study heterogeneity in the immune response at an unprecedented scope. In light of these advances, here we review recent work exploring how immune populations generate and leverage cellular heterogeneity at multiple molecular and phenotypic levels. Additionally, we highlight opportunities for single cell technologies to shed light on the causes and consequences of heterogeneity in the immune system.
AB - The mammalian immune system is tasked with protecting the host against a broad range of threats. Understanding how immune populations leverage cellular diversity to achieve this breadth and flexibility, particularly during dynamic processes such as differentiation and antigenic response, is a core challenge that is well suited for single cell analysis. Recent years have witnessed transformative and intersecting advances in nanofabrication and genomics that enable deep profiling of individual cells, affording exciting opportunities to study heterogeneity in the immune response at an unprecedented scope. In light of these advances, here we review recent work exploring how immune populations generate and leverage cellular heterogeneity at multiple molecular and phenotypic levels. Additionally, we highlight opportunities for single cell technologies to shed light on the causes and consequences of heterogeneity in the immune system.
KW - Cellular heterogeneity
KW - Immune response
KW - Phenotypic variation
KW - Single cell genomics
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U2 - 10.1016/j.it.2014.03.004
DO - 10.1016/j.it.2014.03.004
M3 - Review article
C2 - 24746883
AN - SCOPUS:84899929564
SN - 1471-4906
VL - 35
SP - 219
EP - 229
JO - Trends in Immunology
JF - Trends in Immunology
IS - 5
ER -