Heterogeneous integrated CMOS-graphene sensor array for dopamine detection

Bayan Nasri, Ting Wu, Abdullah Alharbi, Mayank Gupta, Ramkumar Ranjitkumar, Sunit Sebastian, Yue Wang, Roozbeh Kiani, Davood Shahrjerdi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Understanding dopamine (DA) signaling in the brain is essential for advancing our knowledge of pathological disorders such as drug addiction, Parkinson's disease, and schizophrenia. Currently, fast-scan cyclic voltammetry (FSCV) with carbon microfiber (CMF) electrodes is the method of choice in neuroscience labs for monitoring the concentration of phasic (transient) DA release. This method offers sub-second temporal resolution and high specificity because the signal of interest occurs at a known potential. However, existing CMF electrodes are bulky, limiting the spatial resolution to single-site measurements. Further, they are produced through manual processes (e.g. cutting CMFs under optical microscope), thus introducing significant device variability [1]. Lastly, when long probes (3-to-5cm) are used to monitor DA release in deep brain structures of large animals, environmental noise severely diminishes the detection limit [1]. To address these problems, we combine advances in nanofabrication with silicon chip manufacturing to create a heterogeneous integrated CMOS-graphene sensor for accurate measurement of DA with high spatiotemporal resolution (Fig. 15.7.1).

Original languageEnglish (US)
Title of host publication2017 IEEE International Solid-State Circuits Conference, ISSCC 2017
EditorsLaura C. Fujino
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages268-269
Number of pages2
ISBN (Electronic)9781509037575
DOIs
StatePublished - Mar 2 2017
Event64th IEEE International Solid-State Circuits Conference, ISSCC 2017 - San Francisco, United States
Duration: Feb 5 2017Feb 9 2017

Publication series

NameDigest of Technical Papers - IEEE International Solid-State Circuits Conference
Volume60
ISSN (Print)0193-6530

Other

Other64th IEEE International Solid-State Circuits Conference, ISSCC 2017
CountryUnited States
CitySan Francisco
Period2/5/172/9/17

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Heterogeneous integrated CMOS-graphene sensor array for dopamine detection'. Together they form a unique fingerprint.

  • Cite this

    Nasri, B., Wu, T., Alharbi, A., Gupta, M., Ranjitkumar, R., Sebastian, S., Wang, Y., Kiani, R., & Shahrjerdi, D. (2017). Heterogeneous integrated CMOS-graphene sensor array for dopamine detection. In L. C. Fujino (Ed.), 2017 IEEE International Solid-State Circuits Conference, ISSCC 2017 (pp. 268-269). [7870364] (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 60). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ISSCC.2017.7870364