TY - GEN
T1 - Heterogeneous integrated CMOS-graphene sensor array for dopamine detection
AU - Nasri, Bayan
AU - Wu, Ting
AU - Alharbi, Abdullah
AU - Gupta, Mayank
AU - Ranjitkumar, Ramkumar
AU - Sebastian, Sunit
AU - Wang, Yue
AU - Kiani, Roozbeh
AU - Shahrjerdi, Davood
N1 - Publisher Copyright:
© 2017 IEEE.
PY - 2017/3/2
Y1 - 2017/3/2
N2 - Understanding dopamine (DA) signaling in the brain is essential for advancing our knowledge of pathological disorders such as drug addiction, Parkinson's disease, and schizophrenia. Currently, fast-scan cyclic voltammetry (FSCV) with carbon microfiber (CMF) electrodes is the method of choice in neuroscience labs for monitoring the concentration of phasic (transient) DA release. This method offers sub-second temporal resolution and high specificity because the signal of interest occurs at a known potential. However, existing CMF electrodes are bulky, limiting the spatial resolution to single-site measurements. Further, they are produced through manual processes (e.g. cutting CMFs under optical microscope), thus introducing significant device variability [1]. Lastly, when long probes (3-to-5cm) are used to monitor DA release in deep brain structures of large animals, environmental noise severely diminishes the detection limit [1]. To address these problems, we combine advances in nanofabrication with silicon chip manufacturing to create a heterogeneous integrated CMOS-graphene sensor for accurate measurement of DA with high spatiotemporal resolution (Fig. 15.7.1).
AB - Understanding dopamine (DA) signaling in the brain is essential for advancing our knowledge of pathological disorders such as drug addiction, Parkinson's disease, and schizophrenia. Currently, fast-scan cyclic voltammetry (FSCV) with carbon microfiber (CMF) electrodes is the method of choice in neuroscience labs for monitoring the concentration of phasic (transient) DA release. This method offers sub-second temporal resolution and high specificity because the signal of interest occurs at a known potential. However, existing CMF electrodes are bulky, limiting the spatial resolution to single-site measurements. Further, they are produced through manual processes (e.g. cutting CMFs under optical microscope), thus introducing significant device variability [1]. Lastly, when long probes (3-to-5cm) are used to monitor DA release in deep brain structures of large animals, environmental noise severely diminishes the detection limit [1]. To address these problems, we combine advances in nanofabrication with silicon chip manufacturing to create a heterogeneous integrated CMOS-graphene sensor for accurate measurement of DA with high spatiotemporal resolution (Fig. 15.7.1).
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U2 - 10.1109/ISSCC.2017.7870364
DO - 10.1109/ISSCC.2017.7870364
M3 - Conference contribution
AN - SCOPUS:85016258403
T3 - Digest of Technical Papers - IEEE International Solid-State Circuits Conference
SP - 268
EP - 269
BT - 2017 IEEE International Solid-State Circuits Conference, ISSCC 2017
A2 - Fujino, Laura C.
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 64th IEEE International Solid-State Circuits Conference, ISSCC 2017
Y2 - 5 February 2017 through 9 February 2017
ER -