Heteropolymer sequence design and preferential solvation of hydrophilic monomers: Application of random energy model

Longhua Hu, Alexander Y. Grosberg

    Research output: Contribution to journalArticle

    Abstract

    We study the role of the surface of the globule and the role of interactions with the solvent for designed-sequence heteropolymers using the random energy model. We investigate the ground-state energy and surface-monomer composition distribution. By comparing the freezing transition in random and designed-sequence heteropolymers, we discuss the effects of design. Based on our results, we are able to show under which conditions the solvation effect improves the quality of the sequence design. Finally, we study sequence-space entropy and discuss the number of available sequences as a function of the imposed requirements for design quality.

    Original languageEnglish (US)
    Article number041921
    JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
    Volume75
    Issue number4
    DOIs
    StatePublished - Apr 30 2007

    ASJC Scopus subject areas

    • Statistical and Nonlinear Physics
    • Statistics and Probability
    • Condensed Matter Physics

    Fingerprint Dive into the research topics of 'Heteropolymer sequence design and preferential solvation of hydrophilic monomers: Application of random energy model'. Together they form a unique fingerprint.

    Cite this