TY - JOUR
T1 - Heteropolymer sequence design and preferential solvation of hydrophilic monomers
T2 - Application of random energy model
AU - Hu, Longhua
AU - Grosberg, Alexander Y.
PY - 2007/4/30
Y1 - 2007/4/30
N2 - We study the role of the surface of the globule and the role of interactions with the solvent for designed-sequence heteropolymers using the random energy model. We investigate the ground-state energy and surface-monomer composition distribution. By comparing the freezing transition in random and designed-sequence heteropolymers, we discuss the effects of design. Based on our results, we are able to show under which conditions the solvation effect improves the quality of the sequence design. Finally, we study sequence-space entropy and discuss the number of available sequences as a function of the imposed requirements for design quality.
AB - We study the role of the surface of the globule and the role of interactions with the solvent for designed-sequence heteropolymers using the random energy model. We investigate the ground-state energy and surface-monomer composition distribution. By comparing the freezing transition in random and designed-sequence heteropolymers, we discuss the effects of design. Based on our results, we are able to show under which conditions the solvation effect improves the quality of the sequence design. Finally, we study sequence-space entropy and discuss the number of available sequences as a function of the imposed requirements for design quality.
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U2 - 10.1103/PhysRevE.75.041921
DO - 10.1103/PhysRevE.75.041921
M3 - Article
AN - SCOPUS:34247629417
SN - 1539-3755
VL - 75
JO - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
JF - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
IS - 4
M1 - 041921
ER -