@article{15baad24c4cf4f93a34305658d13dba4,
title = "Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon",
abstract = "During forebrain development, a telencephalic organizer called the cortical hem is crucial for inducing hippocampal fate in adjacent cortical neuroepithelium. How the hem is restricted to its medial position is therefore a fundamental patterning issue. Here, we demonstrate that Foxg1-Lhx2 interactions are crucial for the formation of the hem. Loss of either gene causes a region of the cortical neuroepithelium to transform into hem. We show that FOXG1 regulates Lhx2 expression in the cortical primordium. In the absence of Foxg1, the presence of Lhx2 is sufficient to suppress hem fate, and hippocampal markers appear selectively in Lhx2-expressing regions. FOXG1 also restricts the temporal window in which loss of Lhx2 results in a transformation of cortical primordium into hem. Therefore, Foxg1 and Lhx2 form a genetic hierarchy in the spatiotemporal regulation of cortical hem specification and positioning, and together ensure the normal development of this hippocampal organizer.",
keywords = "FOXG1, Hem, Hippocampus, LHX2, Mouse, Patterning, Telencephalon",
author = "Geeta Godbole and Shetty, {Ashwin S.} and Achira Roy and Leora D{\textquoteright}Souza and Bin Chen and Goichi Miyoshi and Gordon Fishell and Shubha Tole",
note = "Funding Information: Energy (S.T.); grants from the National Institutes of Health (R01 NS081297, P01 NS074972 and R01 MH095147 to G.F. and G.M.; R01 MH094589 and R01 NS089777 to B.C.; R01 MH094589 to G.F.); the Simons Foundation (G.F. and G.M.); the Takeda Science Foundation (G.M.); a Shanti Swarup Bhatnagar award from the Council of Scientific and Industrial Research (Government of India) (to S.T.); and the Infosys Prize for Life Sciences from the Infosys Science Foundation (to S.T.). Deposited in PMC for immediate release. Funding Information: This work was supported by a Wellcome Trust/DBT India Alliance Early Career Fellowship (IA/E/11/1/500402 to G.G.); a grant from the Department of Biotechnology, Ministry of Science and Technology, India (PR8681 to S.T.); intramural funds from Tata Institute of Fundamental Research-Department of Atomic Funding Information: This work was supported by a Wellcome Trust/DBT India Alliance Early Career Fellowship (IA/E/11/1/500402 to G.G.); a grant from the Department of Biotechnology, Ministry of Science and Technology, India (PR8681 to S.T.); intramural funds from Tata Institute of Fundamental Research-Department of Atomic Energy (S.T.); grants from the National Institutes of Health (R01 NS081297, P01 NS074972 and R01 MH095147 to G.F. and G.M.; R01 MH094589 and R01 NS089777 to B.C.; R01 MH094589 to G.F.); the Simons Foundation (G.F. and G.M.); the Takeda Science Foundation (G.M.); a Shanti Swarup Bhatnagar award from the Council of Scientific and Industrial Research (Government of India) (to S.T.); and the Infosys Prize for Life Sciences from the Infosys Science Foundation (to S.T.). Deposited in PMC for immediate release. Publisher Copyright: {\textcopyright} 2018. Published by The Company of Biologists Ltd.",
year = "2018",
month = jan,
doi = "10.1242/dev.154583",
language = "English (US)",
volume = "145",
journal = "Development (Cambridge)",
issn = "0950-1991",
publisher = "Company of Biologists Ltd",
number = "1",
}