TY - JOUR
T1 - High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography
AU - Srinivasan, Vivek J.
AU - Wojtkowski, Maciej
AU - Witkin, Andre J.
AU - Duker, Jay S.
AU - Ko, Tony H.
AU - Carvalho, Mariana
AU - Schuman, Joel S.
AU - Kowalczyk, Andrzej
AU - Fujimoto, James G.
N1 - Funding Information:
V. J. Srinivasan acknowledges support from the National Science Foundation Graduate Research Fellowship. T. H. Ko acknowledges support from the Whitaker Foundation.
Funding Information:
Supported in part by the National Institutes of Health, Bethesda, Maryland (contract nos.: R01-EY11289-20, R01-EY13178, P30-EY13078); National Science Foundation, Arlington, Virginia (grant no.: BES-0522845); Air Force Office of Scientific Research, Arlington, Virginia (contract no.: FA9550-040-1-0011); and Medical Free Electron Laser Program, Arlington, Virginia (grant no.: FA9550-040-1-0046).
PY - 2006/11
Y1 - 2006/11
N2 - Objective: To assess high-speed ultrahigh-resolution optical coherence tomography (OCT) image resolution, acquisition speed, image quality, and retinal coverage for the visualization of macular pathologies. Design: Retrospective cross-sectional study. Participants: Five hundred eighty-eight eyes of 327 patients with various macular pathologies. Methods: High-speed ultrahigh-resolution OCT images were obtained in 588 eyes of 327 patients with selected macular diseases. Ultrahigh-resolution OCT using Fourier/spectral domain detection achieves ∼3-μm axial image resolutions, acquisition speeds of ∼25 000 axial scans per second, and >3 times finer resolution and >50 times higher speed than standard OCT. Three scan protocols were investigated. The first acquires a small number of high-definition images through the fovea. The second acquires a raster series of high-transverse pixel density images. The third acquires 3-dimensional OCT data using a dense raster pattern. Three-dimensional OCT can generate OCT fundus images that enable precise registration of OCT images with the fundus. Using the OCT fundus images, OCT results were correlated with standard ophthalmoscopic examination techniques. Main Outcome Measures: High-definition macular pathologies. Results: Macular holes, age-related macular degeneration, epiretinal membranes, diabetic retinopathy, retinal dystrophies, central serous chorioretinopathy, and other pathologies were imaged and correlated with ophthalmic examination, standard OCT, fundus photography, and fluorescein angiography, where applicable. High-speed ultrahigh-resolution OCT generates images of retinal pathologies with improved quality, more comprehensive retinal coverage, and more precise registration than standard OCT. The speed preserves retinal topography, thus enabling the visualization of subtle changes associated with disease. High-definition high-transverse pixel density OCT images improve visualization of photoreceptor and pigment epithelial morphology, as well as thin intraretinal and epiretinal structures. Three-dimensional OCT enables comprehensive retinal coverage, reduces sampling errors, and enables assessment of 3-dimensional pathology. Conclusions: High-definition 3-dimensional imaging using high-speed ultrahigh-resolution OCT improves image quality, retinal coverage, and registration. This new technology has the potential to become a useful tool for elucidating disease pathogenesis and improving disease diagnosis and management.
AB - Objective: To assess high-speed ultrahigh-resolution optical coherence tomography (OCT) image resolution, acquisition speed, image quality, and retinal coverage for the visualization of macular pathologies. Design: Retrospective cross-sectional study. Participants: Five hundred eighty-eight eyes of 327 patients with various macular pathologies. Methods: High-speed ultrahigh-resolution OCT images were obtained in 588 eyes of 327 patients with selected macular diseases. Ultrahigh-resolution OCT using Fourier/spectral domain detection achieves ∼3-μm axial image resolutions, acquisition speeds of ∼25 000 axial scans per second, and >3 times finer resolution and >50 times higher speed than standard OCT. Three scan protocols were investigated. The first acquires a small number of high-definition images through the fovea. The second acquires a raster series of high-transverse pixel density images. The third acquires 3-dimensional OCT data using a dense raster pattern. Three-dimensional OCT can generate OCT fundus images that enable precise registration of OCT images with the fundus. Using the OCT fundus images, OCT results were correlated with standard ophthalmoscopic examination techniques. Main Outcome Measures: High-definition macular pathologies. Results: Macular holes, age-related macular degeneration, epiretinal membranes, diabetic retinopathy, retinal dystrophies, central serous chorioretinopathy, and other pathologies were imaged and correlated with ophthalmic examination, standard OCT, fundus photography, and fluorescein angiography, where applicable. High-speed ultrahigh-resolution OCT generates images of retinal pathologies with improved quality, more comprehensive retinal coverage, and more precise registration than standard OCT. The speed preserves retinal topography, thus enabling the visualization of subtle changes associated with disease. High-definition high-transverse pixel density OCT images improve visualization of photoreceptor and pigment epithelial morphology, as well as thin intraretinal and epiretinal structures. Three-dimensional OCT enables comprehensive retinal coverage, reduces sampling errors, and enables assessment of 3-dimensional pathology. Conclusions: High-definition 3-dimensional imaging using high-speed ultrahigh-resolution OCT improves image quality, retinal coverage, and registration. This new technology has the potential to become a useful tool for elucidating disease pathogenesis and improving disease diagnosis and management.
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U2 - 10.1016/j.ophtha.2006.05.046
DO - 10.1016/j.ophtha.2006.05.046
M3 - Article
C2 - 17074565
AN - SCOPUS:33750285060
SN - 0161-6420
VL - 113
SP - 2054.e1-2054.e14
JO - Ophthalmology
JF - Ophthalmology
IS - 11
ER -