High risk of spontaneous preterm birth among infants with gastroschisis

Rebecca J. Baer, Christina D. Chambers, Kelli K. Ryckman, Scott P. Oltman, Larry Rand, Laura L. Jelliffe-Pawlowski

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the association between gastroschisis and preterm birth (PTB, <37 weeks) by subtype. The sample was drawn from singleton live births in California from 2007 to 2012 contained in a birth cohort file maintained by the California Office of Statewide Health Planning and Development (n = 2,891,965; 1,421 with gastroschisis). Relative risks (RRs) and 95% confidence intervals (CIs) were calculated for PTB by gestational age (<34, 34–36, and any <37 weeks) and by type (spontaneous labor with intact membranes, preterm premature rupture of the membranes [PPROM], provider initiated) and were adjusted for maternal characteristics. Over 44.5% of infants with gastroschisis were born preterm because of spontaneous etiologies; notably, 8.4% of infants with gastroschisis were born <34 weeks because of spontaneous etiologies (adjusted RRs 9.1–12.2). Overall, 53.7% of infants with gastroschisis were born preterm compared with only 6.9% of infants without gastroschisis (adjusted RR 15.2, 95% CI 13.6–19.5) and are at particularly high risk of spontaneous PTB. Nearly 9% of infants with gastroschisis delivered <34 weeks, regardless of preterm etiology, indicating that these infants are at great risk for PTB morbidities in addition to the complications from gastroschisis.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalAmerican Journal of Medical Genetics, Part A
Volume179
Issue number1
DOIs
StatePublished - Jan 2019

Keywords

  • early preterm birth
  • gastroschisis
  • preterm birth
  • spontaneous preterm birth

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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