High-speed, ultrahigh resolution optical coherence tomography of the retina in Hunter syndrome

Michael K. Yoon, Royce W. Chen, Thomas R. Hedges, Vivek J. Srinivasan, Iwona Gorczynska, James G. Fujimoto, Maciej Wojtkowski, Joel S. Schuman, Jay S. Duker

    Research output: Contribution to journalArticlepeer-review

    Abstract

    A 42-year-old man with Hunter syndrome developed bilateral visual field loss. Visual field testing demonstrated bilateral ring scotomata that corresponded to areas of thinning seen on standard resolution optical coherence tomography. High-speed, ultrahigh resolution optical coherence tomography, capable of 3.5-micron axial resolution, showed a loss of photoreceptors outside the fovea and cystoid spaces within the inner nuclear, ganglion cell, and outer nuclear layers. These results were consistent with histopathologic features that have been reported previously in patients with Hunter syndrome. Optical coherence tomography could be used as a diagnostic modality to monitor patients with Hunter syndrome and to detect subclinical forms of disease.

    Original languageEnglish (US)
    Pages (from-to)423-428
    Number of pages6
    JournalOphthalmic Surgery Lasers and Imaging
    Volume38
    Issue number5
    DOIs
    StatePublished - 2007

    ASJC Scopus subject areas

    • Surgery
    • Ophthalmology

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