@inproceedings{d1aaefe96a4e480ab0a67b486f745898,
title = "High-throughput mechanical phenotyping of C. elegans diabetes models using elastomeric micropillar arrays",
abstract = "Using an elastomeric micropillar array on chip, we studied the thrashing force degradation of Caenorhabditis elegans, both wild type and diabetes models, in hyperglycemic conditions. First, we established a quantitative relationship between the magnitude of thrashing force loss and glucose concentration with and without drug treatment. A change in sarcomere morphology of the actin filaments in the body wall muscles supported our finding. Finally, we demonstrated the multiplexing capability of the device by incorporating eight parallel channels for measuring eight worms simultaneously, thereby significantly increasing the throughput.",
keywords = "C. elegans, High-throughput drug screening, Micropillars, Thrashing force",
author = "Samuel Sofela and Sarah Sahloul and Christopher Stubbs and Ajymurat Orozaliev and Song, {Yong Ak}",
note = "Publisher Copyright: {\textcopyright} 2019 CBMS-0001.; 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 ; Conference date: 27-10-2019 Through 31-10-2019",
year = "2019",
language = "English (US)",
series = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019",
publisher = "Chemical and Biological Microsystems Society",
pages = "384--385",
booktitle = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019",
}