Hippocampal-evoked inhibition of cholinergic interneurons in the nucleus accumbens

Corey Baimel, Emily Jang, Samantha L. Scudder, Kasra Manoocheri, Adam G. Carter

Research output: Contribution to journalArticlepeer-review


Cholinergic interneurons (ChIs) in the nucleus accumbens (NAc) play a central role in motivated behaviors and associated disorders. However, while the activation of ChIs has been well studied in the dorsal striatum, little is known about how they are engaged in the NAc. Here, we find that the ventral hippocampus (vHPC) and the paraventricular nucleus of the thalamus (PVT) are the main excitatory inputs to ChIs in the NAc medial shell. While the PVT activates ChIs, the vHPC evokes a pronounced pause in firing through prominent feedforward inhibition. In contrast to the dorsal striatum, this inhibition reflects strong connections onto ChIs from local parvalbumin interneurons. Our results reveal the mechanisms by which different long-range inputs engage ChIs, highlighting fundamental differences in local connectivity across the striatum.

Original languageEnglish (US)
Article number111042
JournalCell Reports
Issue number1
StatePublished - Jul 5 2022


  • CP: Neuroscience
  • cholinergic interneuron
  • hippocampus
  • inhibition
  • nucleus accumbens
  • thalamus

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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