Histological and nanomechanical properties of a new nanometric hydroxiapatite implant surface. An in vivo study in diabetic rats

Paula G.F.P. Oliveira, Paulo G. Coelho, Edmara T.P. Bergamo, Lukasz Witek, Cristine A. Borges, Fábio B. Bezerra, Arthur B. Novaes, Sergio L.S. Souza

Research output: Contribution to journalArticlepeer-review

Abstract

Implant therapy is a predictable treatment to replace missing teeth. However, the osseointegration process may be negatively influenced by systemic conditions, such as diabetes mellitus (DM). Microtopography and implant surface developments are strategies associated to better bone repair. This study aimed to evaluate, in healthy and diabetic rats, histomorphometric (bone to implant contact = %BIC; and bone area fraction occupancy = %BAFO) and nanomechanical (elastic modulus = EM; and hardness = H) bone parameters, in response to a nanometric hydroxyapatite implant surface. Mini implants (machined = MAC; double acid etched = DAE, and with addition of nano-hydroxyapatite = NANO) were installed in tibias of healthy and diabetic rats. The animals were euthanized at 7 and 30 days. NANO surface presented higher %BIC and %BAFO when compared to MAC and DAE (data evaluated as a function of implant surface). NANO surface presented higher %BIC and %BAFO, with statistically significant differences (data as a function of time and implant surface). NANO surface depicted higher EM and H values, when compared to machined and DAE surfaces (data as a function of time and implant surface). Nano-hydroxyapatite coated implants presented promising biomechanical results and could be an important tool to compensate impaired bone healing reported in diabetics.

Original languageEnglish (US)
Article number5693
Pages (from-to)1-17
Number of pages17
JournalMaterials
Volume13
Issue number24
DOIs
StatePublished - Dec 2 2020

Keywords

  • Dental implants
  • Diabetes mellitus
  • Histology

ASJC Scopus subject areas

  • Materials Science(all)

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