Histomorphometric comparison of different concentrations of recombinant human bone morphogenetic protein with allogeneic bone compared to the use of 100% mineralized cancellous bone allograft in maxillary sinus grafting

Stuart J. Froum; Stephen Wallace; Sang Choon Cho; Ismael Khouly; Edwin Rosenberg; Patricia Corby; Scott Froum; Timothy Bromage; Robert Schoor; Robert Norman; Dennis P. Tarnow

doi:10.11607/prd.1736

Histomorphometric comparison of different concentrations of recombinant human bone morphogenetic protein with allogeneic bone compared to the use of 100% mineralized cancellous bone allograft in maxillary sinus grafting

Stuart J. Froum, Stephen Wallace, Sang Choon Cho, Ismael Khouly, Edwin Rosenberg, Patricia Corby, Scott Froum, Timothy Bromage, Robert Schoor, Robert Norman, Dennis P. Tarnow

Research output: Contribution to journal › Article › peer-review

Abstract

The purpose of this study was to histomorphometrically evaluate the percentage of vital bone after grafting of maxillary sinuses using two different concentrations of recombinant human bone morphogenetic protein/acellular collagen sponge (rhBMP-2/ACS) combined with mineralized cancellous bone allograft (MCBA) and to compare the results to a control sinus grafted with MCBA only. Thirty-six sinuses in 18 patients had two of three of the graft combinations including: (1) control, MCBA only; (2) test one, MCBA + 5.6 mL of rhBMP-2/ACS (containing 8.4 mg of rhBMP-2); or (3) test two, MCBA + 2.8 mL of rhBMP-2/ACS (containing 4.2 mg of rhBMP-2). Histologic cores were taken 6 to 9 month following sinus augmentation. The results showed no statistically significant differences in vital bone between the two test groups compared to the control sinus group treated with MCBA alone. Future studies involving more cases and evaluating survival of implants placed in these augmented sinuses are needed to verify the results of this randomized prospective study.

Original language	English (US)
Pages (from-to)	721-730
Number of pages	10
Journal	International Journal of Periodontics and Restorative Dentistry
Volume	33
Issue number	6
DOIs	https://doi.org/10.11607/prd.1736
State	Published - 2013

ASJC Scopus subject areas

General Medicine

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Froum, S. J., Wallace, S., Cho, S. C., Khouly, I., Rosenberg, E., Corby, P., Froum, S., Bromage, T., Schoor, R., Norman, R., & Tarnow, D. P. (2013). Histomorphometric comparison of different concentrations of recombinant human bone morphogenetic protein with allogeneic bone compared to the use of 100% mineralized cancellous bone allograft in maxillary sinus grafting. International Journal of Periodontics and Restorative Dentistry, 33(6), 721-730. https://doi.org/10.11607/prd.1736

Histomorphometric comparison of different concentrations of recombinant human bone morphogenetic protein with allogeneic bone compared to the use of 100% mineralized cancellous bone allograft in maxillary sinus grafting. / Froum, Stuart J.; Wallace, Stephen; Cho, Sang Choon et al.
In: International Journal of Periodontics and Restorative Dentistry, Vol. 33, No. 6, 2013, p. 721-730.

Research output: Contribution to journal › Article › peer-review

Froum, SJ, Wallace, S, Cho, SC, Khouly, I, Rosenberg, E, Corby, P, Froum, S, Bromage, T, Schoor, R, Norman, R & Tarnow, DP 2013, 'Histomorphometric comparison of different concentrations of recombinant human bone morphogenetic protein with allogeneic bone compared to the use of 100% mineralized cancellous bone allograft in maxillary sinus grafting', International Journal of Periodontics and Restorative Dentistry, vol. 33, no. 6, pp. 721-730. https://doi.org/10.11607/prd.1736

Froum SJ, Wallace S, Cho SC, Khouly I, Rosenberg E, Corby P et al. Histomorphometric comparison of different concentrations of recombinant human bone morphogenetic protein with allogeneic bone compared to the use of 100% mineralized cancellous bone allograft in maxillary sinus grafting. International Journal of Periodontics and Restorative Dentistry. 2013;33(6):721-730. doi: 10.11607/prd.1736

Froum, Stuart J. ; Wallace, Stephen ; Cho, Sang Choon et al. / Histomorphometric comparison of different concentrations of recombinant human bone morphogenetic protein with allogeneic bone compared to the use of 100% mineralized cancellous bone allograft in maxillary sinus grafting. In: International Journal of Periodontics and Restorative Dentistry. 2013 ; Vol. 33, No. 6. pp. 721-730.

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abstract = "The purpose of this study was to histomorphometrically evaluate the percentage of vital bone after grafting of maxillary sinuses using two different concentrations of recombinant human bone morphogenetic protein/acellular collagen sponge (rhBMP-2/ACS) combined with mineralized cancellous bone allograft (MCBA) and to compare the results to a control sinus grafted with MCBA only. Thirty-six sinuses in 18 patients had two of three of the graft combinations including: (1) control, MCBA only; (2) test one, MCBA + 5.6 mL of rhBMP-2/ACS (containing 8.4 mg of rhBMP-2); or (3) test two, MCBA + 2.8 mL of rhBMP-2/ACS (containing 4.2 mg of rhBMP-2). Histologic cores were taken 6 to 9 month following sinus augmentation. The results showed no statistically significant differences in vital bone between the two test groups compared to the control sinus group treated with MCBA alone. Future studies involving more cases and evaluating survival of implants placed in these augmented sinuses are needed to verify the results of this randomized prospective study.",

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AU - Rosenberg, Edwin

AU - Corby, Patricia

AU - Froum, Scott

AU - Bromage, Timothy

AU - Schoor, Robert

AU - Norman, Robert

AU - Tarnow, Dennis P.

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AB - The purpose of this study was to histomorphometrically evaluate the percentage of vital bone after grafting of maxillary sinuses using two different concentrations of recombinant human bone morphogenetic protein/acellular collagen sponge (rhBMP-2/ACS) combined with mineralized cancellous bone allograft (MCBA) and to compare the results to a control sinus grafted with MCBA only. Thirty-six sinuses in 18 patients had two of three of the graft combinations including: (1) control, MCBA only; (2) test one, MCBA + 5.6 mL of rhBMP-2/ACS (containing 8.4 mg of rhBMP-2); or (3) test two, MCBA + 2.8 mL of rhBMP-2/ACS (containing 4.2 mg of rhBMP-2). Histologic cores were taken 6 to 9 month following sinus augmentation. The results showed no statistically significant differences in vital bone between the two test groups compared to the control sinus group treated with MCBA alone. Future studies involving more cases and evaluating survival of implants placed in these augmented sinuses are needed to verify the results of this randomized prospective study.

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Histomorphometric comparison of different concentrations of recombinant human bone morphogenetic protein with allogeneic bone compared to the use of 100% mineralized cancellous bone allograft in maxillary sinus grafting

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