Hit-and-Run leaves its mark: Catalyst transcription factors and chromatin modification

Kranthi Varala, Ying Li, Amy Marshall-Colón, Alessia Para, Gloria M. Coruzzi

Research output: Contribution to journalArticlepeer-review


Understanding how transcription factor (TF) binding is related to gene regulation is a moving target. We recently uncovered genome-wide evidence for a Hit-and-Run model of transcription. In this model, a master TF hits a target promoter to initiate a rapid response to a signal. As the hit is transient, the model invokes recruitment of partner TFs to sustain transcription over time. Following the run, the master TF hits other targets to propagate the response genome-wide. As such, a TF may act as a catalyst to mount a broad and acute response in cells that first sense the signal, while the recruited TF partners promote long-term adaptive behavior in the whole organism. This Hit-and-Run model likely has broad relevance, as TF perturbation studies across eukaryotes show small overlaps between TF-regulated and TF-bound genes, implicating transient TF-target binding. Here, we explore this Hit-and-Run model to suggest molecular mechanisms and its biological relevance.

Original languageEnglish (US)
Pages (from-to)851-856
Number of pages6
Issue number8
StatePublished - Aug 1 2015


  • "Hit-and-Run"
  • Dynamic regulation
  • Gene regulatory networks
  • TF binding
  • Transcriptional model
  • Transcriptional regulation

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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