Abstract
Understanding how transcription factor (TF) binding is related to gene regulation is a moving target. We recently uncovered genome-wide evidence for a Hit-and-Run model of transcription. In this model, a master TF hits a target promoter to initiate a rapid response to a signal. As the hit is transient, the model invokes recruitment of partner TFs to sustain transcription over time. Following the run, the master TF hits other targets to propagate the response genome-wide. As such, a TF may act as a catalyst to mount a broad and acute response in cells that first sense the signal, while the recruited TF partners promote long-term adaptive behavior in the whole organism. This Hit-and-Run model likely has broad relevance, as TF perturbation studies across eukaryotes show small overlaps between TF-regulated and TF-bound genes, implicating transient TF-target binding. Here, we explore this Hit-and-Run model to suggest molecular mechanisms and its biological relevance.
Original language | English (US) |
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Pages (from-to) | 851-856 |
Number of pages | 6 |
Journal | BioEssays |
Volume | 37 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1 2015 |
Keywords
- "Hit-and-Run"
- Dynamic regulation
- Gene regulatory networks
- TF binding
- Transcriptional model
- Transcriptional regulation
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)