HiTSEE: A visualization tool for hit selection and analysis in high-throughput screening experiments

Enrico Bertini; Hendrik Strobelt; Joachim Braun; Oliver Deussen; Ulrich Groth; Thomas U. Mayer; Dorit Merhof

doi:10.1109/BioVis.2011.6094053

HiTSEE: A visualization tool for hit selection and analysis in high-throughput screening experiments

Enrico Bertini, Hendrik Strobelt, Joachim Braun, Oliver Deussen, Ulrich Groth, Thomas U. Mayer, Dorit Merhof

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We present HiTSEE (High-Throughput Screening Exploration Environment) a visualization tool for the analysis of large chemical screens for the analysis of biochemical processes. The tool supports the analysis of structure-activity relationships (SAR analysis) and, through a flexible interaction mechanism, the navigation of large chemical spaces. Our approach based on the projection of one or few molecules of interest and the expansion around their neighborhood allows for the exploration of large chemical libraries without the need to create an all encompassing overview of the whole library. We describe the requirements we collected during our collaboration with biologists and chemists, the design rationale behind the tool, and two case studies.

Original language	English (US)
Title of host publication	IEEE Symposium on Biological Data Visualization 2011, BioVis 2011 - Proceedings
Pages	95-102
Number of pages	8
DOIs	https://doi.org/10.1109/BioVis.2011.6094053
State	Published - 2011
Event	1st IEEE Symposium on Biological Data Visualization, BioVis 2011 - Providence, RI, United States Duration: Oct 23 2011 → Oct 24 2011

Publication series

Name	IEEE Symposium on Biological Data Visualization 2011, BioVis 2011 - Proceedings

Other

Other	1st IEEE Symposium on Biological Data Visualization, BioVis 2011
Country/Territory	United States
City	Providence, RI
Period	10/23/11 → 10/24/11

ASJC Scopus subject areas

Biotechnology
Computer Vision and Pattern Recognition
Information Systems

Access to Document

10.1109/BioVis.2011.6094053

Cite this

Bertini, E., Strobelt, H., Braun, J., Deussen, O., Groth, U., Mayer, T. U., & Merhof, D. (2011). HiTSEE: A visualization tool for hit selection and analysis in high-throughput screening experiments. In IEEE Symposium on Biological Data Visualization 2011, BioVis 2011 - Proceedings (pp. 95-102). Article 6094053 (IEEE Symposium on Biological Data Visualization 2011, BioVis 2011 - Proceedings). https://doi.org/10.1109/BioVis.2011.6094053

HiTSEE: A visualization tool for hit selection and analysis in high-throughput screening experiments. / Bertini, Enrico; Strobelt, Hendrik; Braun, Joachim et al.
IEEE Symposium on Biological Data Visualization 2011, BioVis 2011 - Proceedings. 2011. p. 95-102 6094053 (IEEE Symposium on Biological Data Visualization 2011, BioVis 2011 - Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Bertini, E, Strobelt, H, Braun, J, Deussen, O, Groth, U, Mayer, TU & Merhof, D 2011, HiTSEE: A visualization tool for hit selection and analysis in high-throughput screening experiments. in IEEE Symposium on Biological Data Visualization 2011, BioVis 2011 - Proceedings., 6094053, IEEE Symposium on Biological Data Visualization 2011, BioVis 2011 - Proceedings, pp. 95-102, 1st IEEE Symposium on Biological Data Visualization, BioVis 2011, Providence, RI, United States, 10/23/11. https://doi.org/10.1109/BioVis.2011.6094053

Bertini E, Strobelt H, Braun J, Deussen O, Groth U, Mayer TU et al. HiTSEE: A visualization tool for hit selection and analysis in high-throughput screening experiments. In IEEE Symposium on Biological Data Visualization 2011, BioVis 2011 - Proceedings. 2011. p. 95-102. 6094053. (IEEE Symposium on Biological Data Visualization 2011, BioVis 2011 - Proceedings). doi: 10.1109/BioVis.2011.6094053

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HiTSEE: A visualization tool for hit selection and analysis in high-throughput screening experiments

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