HIV-1 acquisition and disease progression are associated with decreased high-risk sexual behaviour among Kenyan female sex workers

R. Scott McClelland, Wisal M. Hassan, Ludo Lavreys, Barbra A. Richardson, Kishorchandra Mandaliya, Jeckoniah Ndinya-Achola, Walter Jaoko, Ann E. Kurth, Jared M. Baeten

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Changes in sexual risk behaviour may occur following HIV-1 infection. OBJECTIVE: To test the hypothesis that HIV-1 seroconversion and disease progression are associated with changes in risk behaviours, using data from a cohort of Kenyan female sex workers (FSWs). METHODS: HIV-1-seronegative FSWs were enrolled in a prospective cohort study of risk factors for HIV-1 acquisition. At monthly visits, standardized interviews were conducted to assess sexual risk behaviour and HIV-1 serologic testing was performed. Seroconverters were invited to continue with follow-up. Between 1993 and 2004 (when antiretroviral therapy was introduced in the cohort), 265 women seroconverted for HIV-1 (incidence 7.7/100 person-years) and were included in this analysis. RESULTS: Unprotected intercourse was reported at 546/2037 (27%) pre-seroconversion visits versus 557/3732 (15%) post-seroconversion visits (P < 0.001). These findings remained significant after adjustment for potential confounding factors [adjusted odds ratio (AOR) 0.69; 95% confidence interval (CI), 0.55-0.86]. Compared with HIV-1-seronegative women, there was a progressive stepwise decrease in unprotected intercourse among HIV-1-seropositive women with CD4 cell counts ≥ 500 (AOR, 0.93; 95% CI, 0.62-1.39), 200-499 (AOR, 0.58; 95% CI, 0.41-0.82) and < 200 cells/μl (AOR, 0.45; 95% CI, 0.25-0.82). Decreases in unprotected intercourse reflected increases in both abstinence and 100% condom use. Women also reported fewer partners and fewer episodes of intercourse after HIV-1 seroconversion. CONCLUSIONS: HIV-1 seroconversion and disease progression were associated with decreases in sexual risk behaviour among Kenyan FSWs.

Original languageEnglish (US)
Pages (from-to)1969-1973
Number of pages5
JournalAIDS
Volume20
Issue number15
DOIs
StatePublished - Oct 2006
Externally publishedYes

Keywords

  • Behaviour
  • HIV
  • Prevention
  • Seroconversion
  • Women

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    McClelland, R. S., Hassan, W. M., Lavreys, L., Richardson, B. A., Mandaliya, K., Ndinya-Achola, J., Jaoko, W., Kurth, A. E., & Baeten, J. M. (2006). HIV-1 acquisition and disease progression are associated with decreased high-risk sexual behaviour among Kenyan female sex workers. AIDS, 20(15), 1969-1973. https://doi.org/10.1097/01.aids.0000247119.12327.e6