HIV-1 prevention for HIV-1 serodiscordant couples

Kathryn Curran, Jared M. Baeten, Thomas J. Coates, Ann Kurth, Nelly R. Mugo, Connie Celum

Research output: Contribution to journalArticlepeer-review


A substantial proportion of HIV-1 infected individuals in sub-Saharan Africa are in stable relationships with HIV-1 uninfected partners, and HIV-1 serodiscordant couples thus represent an important target population for HIV-1 prevention. Couple-based HIV-1 testing and counseling facilitates identification of HIV-1 serodiscordant couples, counseling about risk reduction, and referrals to HIV-1 treatment, reproductive health services, and support services. Maximizing HIV-1 prevention for HIV-1 serodiscordant couples requires a combination of strategies, including counseling about condoms, sexual risk, fertility, contraception, and the clinical and prevention benefits of antiretroviral therapy (ART) for the HIV-1-infected partner; provision of clinical care and ART for the HIV-1-infected partner; antenatal care and services to prevent mother-to-child transmission for HIV-1-infected pregnant women; male circumcision for HIV-1-uninfected men; and, pending guidelines and demonstration projects, oral pre-exposure prophylaxis (PrEP) for HIV-1-uninfected partners.

Original languageEnglish (US)
Pages (from-to)160-170
Number of pages11
JournalCurrent HIV/AIDS Reports
Issue number2
StatePublished - Jun 2012


  • ART
  • Africa
  • Antiretroviral
  • HIV-1 Serodiscordant couples
  • HIV-1 prevention
  • PrEP

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


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