TY - JOUR
T1 - HIV-1 prevention for HIV-1 serodiscordant couples
AU - Curran, Kathryn
AU - Baeten, Jared M.
AU - Coates, Thomas J.
AU - Kurth, Ann
AU - Mugo, Nelly R.
AU - Celum, Connie
N1 - Funding Information:
Funding: the Bill and Melinda Gates Foundation (47674) and the National Institutes of Health (R01 AI083034, R21 NR012663, and R01 MH095507).
PY - 2012/6
Y1 - 2012/6
N2 - A substantial proportion of HIV-1 infected individuals in sub-Saharan Africa are in stable relationships with HIV-1 uninfected partners, and HIV-1 serodiscordant couples thus represent an important target population for HIV-1 prevention. Couple-based HIV-1 testing and counseling facilitates identification of HIV-1 serodiscordant couples, counseling about risk reduction, and referrals to HIV-1 treatment, reproductive health services, and support services. Maximizing HIV-1 prevention for HIV-1 serodiscordant couples requires a combination of strategies, including counseling about condoms, sexual risk, fertility, contraception, and the clinical and prevention benefits of antiretroviral therapy (ART) for the HIV-1-infected partner; provision of clinical care and ART for the HIV-1-infected partner; antenatal care and services to prevent mother-to-child transmission for HIV-1-infected pregnant women; male circumcision for HIV-1-uninfected men; and, pending guidelines and demonstration projects, oral pre-exposure prophylaxis (PrEP) for HIV-1-uninfected partners.
AB - A substantial proportion of HIV-1 infected individuals in sub-Saharan Africa are in stable relationships with HIV-1 uninfected partners, and HIV-1 serodiscordant couples thus represent an important target population for HIV-1 prevention. Couple-based HIV-1 testing and counseling facilitates identification of HIV-1 serodiscordant couples, counseling about risk reduction, and referrals to HIV-1 treatment, reproductive health services, and support services. Maximizing HIV-1 prevention for HIV-1 serodiscordant couples requires a combination of strategies, including counseling about condoms, sexual risk, fertility, contraception, and the clinical and prevention benefits of antiretroviral therapy (ART) for the HIV-1-infected partner; provision of clinical care and ART for the HIV-1-infected partner; antenatal care and services to prevent mother-to-child transmission for HIV-1-infected pregnant women; male circumcision for HIV-1-uninfected men; and, pending guidelines and demonstration projects, oral pre-exposure prophylaxis (PrEP) for HIV-1-uninfected partners.
KW - ART
KW - Africa
KW - Antiretroviral
KW - HIV-1 Serodiscordant couples
KW - HIV-1 prevention
KW - PrEP
UR - http://www.scopus.com/inward/record.url?scp=84864002367&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864002367&partnerID=8YFLogxK
U2 - 10.1007/s11904-012-0114-z
DO - 10.1007/s11904-012-0114-z
M3 - Article
C2 - 22415473
AN - SCOPUS:84864002367
SN - 1548-3568
VL - 9
SP - 160
EP - 170
JO - Current HIV/AIDS Reports
JF - Current HIV/AIDS Reports
IS - 2
ER -