HIV-2 infection in an American

Thomas R. O'Brien, Charlene Polon, Charles A. Schable, Nancy VanDevanter, Mark A. Rayfield, David Wallace, Ann Stuart, Scott D. Holmberg

Research output: Contribution to journalArticlepeer-review


HIV-2 is endemic in West Africa but rare elsewhere. In the USA there have been 18 reported cases of HIV-2 infection; most identified people have been West Africans. We recently diagnosed the first case of HIV-2 infection in a native-born US citizen, a woman whose serum was found to be reactive to anti-HIV-1 enzyme immunoassay (EIA) when she attempted to donate blood in 1986. Although both HIV-1- and HIV-2-specific EIAs were reactive, the anti-HIV-2 Western blot (WB) was positive, while the anti-HIV-1 WB was positive or indeterminate on different occasions. Synthetic peptide testing was reactive for HIV-2 but not HIV-1. HIV-2 DNA was detected using the polymerase chain reaction procedure. Although she had travelled to West Africa, it is unclear how she became infected with HIV-2.

Original languageEnglish (US)
Pages (from-to)85-88
Number of pages4
Issue number1
StatePublished - Jan 1991


  • AIDS
  • Epidemiology
  • HIV-2
  • Surveillance
  • United States

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Immunology


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