@article{f0062623f86e4125b85af38e7357a008,
title = "HIV control programs reduce HIV incidence but not HCV incidence among people who inject drugs in HaiPhong, Vietnam",
abstract = "In Vietnam, harm reduction programs to control HIV among people who inject drugs (PWID) were implemented approximately 10 years ago. Since then, the HIV prevalence has declined in this population, however, the impact of these programs on the rate of new HIV and Hepatitis C (HCV) infections remains unknown as high mortality can exceed the rate of new infections. We evaluated HIV and HCV incidences in a cohort of active PWID in HaiPhong in 2014, who were recruited from a community-based respondent driven sampling (RDS) survey and followed for 1 year. Only HIV-negative or HCV-negative participants not on medication assisted treatment (MAT) were eligible. HIV/HCV serology was tested at enrollment and at 32- and 64-week follow-up visits. Among 603 RDS participants, 250 were enrolled in the cohort, including 199 HIV seronegative and 99 HCV seronegative PWID. No HIV seroconversion was reported during the 206 person-years (PY) of follow-up (HIV incidence of 0/100PY, one-sided 97.5%CI:0-1.8/100 PY). Eighteen HCV seroconversions were reported for an incidence of 19.4/100 PY (95%CI;11.5-30.7). In multivariate analysis, “Injecting more than twice daily” was associated with HCV seroconversion with an adjusted odds ratio of 5.8 (95%CI;1.8–18.1). In Hai Phong, in a context that demonstrates the effectiveness of HIV control programs, the HCV incidence remains high. New strategies such as mass access to HCV treatment should be evaluated in order to tackle HCV transmission among PWID.",
author = "Mol{\`e}s, {Jean Pierre} and Roselyne Vallo and Khue, {Pham Minh} and Huong, {Duong Thi} and Oanh, {Khuat Thi Hai} and Thoa, {Nguyen Thi} and Giang, {Hoang Thi} and Thanh, {Nham Thi Tuyet} and Vinh, {Vu Hai} and {Bui Thi}, {Tuyet Anh} and Marianne Peries and Kamyar Arasteh and Catherine Quillet and Jonathan Feelemyer and Laurent Michel and Jarlais, {Don Des} and Didier Laureillard and Nicolas Nagot",
note = "Funding Information: This work was supported by the French “Agence Nationale de Recherche sur le SIDA et les h{\'e}patites virales” [#12299 & #12353] and US National Institute of Drug Abuse [#P30DA011041 & #R01DA041978]. Expertise France funded the HCV viral loads. The funding agencies did not interfere neither with the design of the study nor with the interpretation of the results. We are grateful to Provincial Health authorities and Viet Tiep hospital direction for their continuous support during the study. We want to specifically acknowledge Dr. Vu Van Cong, Pr. Truong Thi Xuan Lien and Pr. F. Barr{\'e}-Sinoussi (ANRS Vietnam site coordinators) for their help at the early stage of the project and their inestimable advices. Composition of DRIVE study team: Vu Van Cong, Nguyen Van Dinh, Cao Thi Kim Giang, Nguyen Thanh Hai, Ted Hammet, Hoang Thi Hoa Le, Marie Jauffret Roustide, Le Thi Loan, Nguyen Hoang Long, Dang Thi Ly, Nguyen Huu Nhan, Dao Nhat Quyen, Vu Minh Son, Nguyen Thi Thanh, Doan Thi Thu, Nguyen Thi Thu. Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = dec,
day = "1",
doi = "10.1038/s41598-020-63990-w",
language = "English (US)",
volume = "10",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}