Holographic microrheology of polysaccharides from Streptococcus mutans biofilms

Fook Chiong Cheong, Simone Duarte, Sang Hyuk Lee, David G. Grier

    Research output: Contribution to journalArticlepeer-review


    We use three-dimensional holographic particle tracking to perform microrheological measurements of model gelled media, including the polysaccharide pellicle of dental biofilms created by the common cariogenic oral pathogen Streptococcus mutans. Nanometer-resolution video-rate holographic tracking of embedded colloidal spheres provides accurate measurements of the gels' complex viscoelastic moduli, including insights into these properties' heterogeneity. When applied to polysaccharides of S. mutans biofilms, these techniques promise quantitative microscopic assays for candidate therapeutic agents against cariogenic dental biofilms.

    Original languageEnglish (US)
    Pages (from-to)109-115
    Number of pages7
    JournalRheologica Acta
    Issue number1
    StatePublished - 2009


    • Biofilms
    • Microrheology
    • Polysaccharide gel
    • Streptococcus mutans
    • Video holographic microscopy

    ASJC Scopus subject areas

    • General Materials Science
    • Condensed Matter Physics


    Dive into the research topics of 'Holographic microrheology of polysaccharides from Streptococcus mutans biofilms'. Together they form a unique fingerprint.

    Cite this