Holographic microrheology of polysaccharides from Streptococcus mutans biofilms

Fook Chiong Cheong; Simone Duarte; Sang Hyuk Lee; David G. Grier

doi:10.1007/s00397-008-0320-1

Holographic microrheology of polysaccharides from Streptococcus mutans biofilms

Fook Chiong Cheong, Simone Duarte, Sang Hyuk Lee, David G. Grier

Research output: Contribution to journal › Article › peer-review

Abstract

We use three-dimensional holographic particle tracking to perform microrheological measurements of model gelled media, including the polysaccharide pellicle of dental biofilms created by the common cariogenic oral pathogen Streptococcus mutans. Nanometer-resolution video-rate holographic tracking of embedded colloidal spheres provides accurate measurements of the gels' complex viscoelastic moduli, including insights into these properties' heterogeneity. When applied to polysaccharides of S. mutans biofilms, these techniques promise quantitative microscopic assays for candidate therapeutic agents against cariogenic dental biofilms.

Original language	English (US)
Pages (from-to)	109-115
Number of pages	7
Journal	Rheologica Acta
Volume	48
Issue number	1
DOIs	https://doi.org/10.1007/s00397-008-0320-1
State	Published - 2009

Keywords

Biofilms
Microrheology
Polysaccharide gel
Streptococcus mutans
Video holographic microscopy

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics

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10.1007/s00397-008-0320-1

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title = "Holographic microrheology of polysaccharides from Streptococcus mutans biofilms",

abstract = "We use three-dimensional holographic particle tracking to perform microrheological measurements of model gelled media, including the polysaccharide pellicle of dental biofilms created by the common cariogenic oral pathogen Streptococcus mutans. Nanometer-resolution video-rate holographic tracking of embedded colloidal spheres provides accurate measurements of the gels' complex viscoelastic moduli, including insights into these properties' heterogeneity. When applied to polysaccharides of S. mutans biofilms, these techniques promise quantitative microscopic assays for candidate therapeutic agents against cariogenic dental biofilms.",

keywords = "Biofilms, Microrheology, Polysaccharide gel, Streptococcus mutans, Video holographic microscopy",

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AB - We use three-dimensional holographic particle tracking to perform microrheological measurements of model gelled media, including the polysaccharide pellicle of dental biofilms created by the common cariogenic oral pathogen Streptococcus mutans. Nanometer-resolution video-rate holographic tracking of embedded colloidal spheres provides accurate measurements of the gels' complex viscoelastic moduli, including insights into these properties' heterogeneity. When applied to polysaccharides of S. mutans biofilms, these techniques promise quantitative microscopic assays for candidate therapeutic agents against cariogenic dental biofilms.

KW - Biofilms

KW - Microrheology

KW - Polysaccharide gel

KW - Streptococcus mutans

KW - Video holographic microscopy

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Holographic microrheology of polysaccharides from Streptococcus mutans biofilms

Abstract

Keywords

ASJC Scopus subject areas

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