Fuzz testing is often automated, but also frequently augmented by experts who insert themselves into the workflow in a greedy search for bugs. In this paper, we propose Homo in Machina, or HM-fuzzing, in which analyses guide the manual efforts, maximizing benefit. As one example of this paradigm, we introduce compartment analysis. Compartment analysis uses a whole-program dominator analysis to estimate the utility of reaching new code, and combines this with a dynamic analysis indicating drastically under-covered edges guarding that code. This results in a prioritized list of compartments, i.e., large, uncovered parts of the pro-gram semantically partitioned and largely unreachable given the current corpus of inputs under consideration. A human can use this categorization and ranking of compartments directly to focus manual effort, finding or fashioning inputs that make the compartments available for future fuzzing. We evaluate the effect of compartment analysis on seven projects within the OSS-Fuzz corpus where we see coverage improvements over AFL++ as high as 94%, with a median of 13%. We further observe that the determination of compartments is highly stable and thus can be done early in a fuzzing campaign, maximizing the potential for impact.