Homologous regulation of 5-HT1A receptor mRNA in adult rat hippocampal dentate gyrus

Jie Huang; Efrain C. Azmitia

doi:10.1016/S0304-3940(99)00439-5

Homologous regulation of 5-HT1A receptor mRNA in adult rat hippocampal dentate gyrus

Jie Huang, Efrain C. Azmitia

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Short-term adrenalectomy induces a loss of mature granular neuronal phenotypes in the hippocampal dentate gyrus; injection of 5-HT1A receptor agonist reverses this effect. Adrenalectomy also induces an increase of expression of 5-HT1A receptor mRNA in the dentate gyrus. This study tested the effect of 5-HT1A agonist on this adrenalectomy-induced increase of 5- HT1A mRNA. Five, 9 and 18 days after adrenalectomy, 5-HT1A receptor mRNA is increased in the granular layer of the dentate gyrus. The increase is nearly 100% at day 18 after adrenalectomy. 5-HT1A agonist treatment decreased 5- HT1A mRNA both at 9 (20%) and 18 days (34%) after adrenalectomy. Our results indicated that a 5-HT1A agonist can partly reverse the adrenalectomy-induced increase of 5-HT1A mRNA and loss of mature granular neuronal phenotypes in hippocampal dentate gyrus.

Original language	English (US)
Pages (from-to)	5-8
Number of pages	4
Journal	Neuroscience letters
Volume	270
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(99)00439-5
State	Published - Jul 23 1999

Keywords

Adrenalectomy
In situ hybridization
Ipsapirone
Neuroplasticity
Neurotrophic factor
Serotonin
Steroids

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(99)00439-5

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title = "Homologous regulation of 5-HT1A receptor mRNA in adult rat hippocampal dentate gyrus",

abstract = "Short-term adrenalectomy induces a loss of mature granular neuronal phenotypes in the hippocampal dentate gyrus; injection of 5-HT1A receptor agonist reverses this effect. Adrenalectomy also induces an increase of expression of 5-HT1A receptor mRNA in the dentate gyrus. This study tested the effect of 5-HT1A agonist on this adrenalectomy-induced increase of 5- HT1A mRNA. Five, 9 and 18 days after adrenalectomy, 5-HT1A receptor mRNA is increased in the granular layer of the dentate gyrus. The increase is nearly 100% at day 18 after adrenalectomy. 5-HT1A agonist treatment decreased 5- HT1A mRNA both at 9 (20%) and 18 days (34%) after adrenalectomy. Our results indicated that a 5-HT1A agonist can partly reverse the adrenalectomy-induced increase of 5-HT1A mRNA and loss of mature granular neuronal phenotypes in hippocampal dentate gyrus.",

keywords = "Adrenalectomy, In situ hybridization, Ipsapirone, Neuroplasticity, Neurotrophic factor, Serotonin, Steroids",

author = "Jie Huang and Azmitia, {Efrain C.}",

note = "Funding Information: This research was supported by the National Institute of Mental Health Grant NIMH-NIH-55250.",

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AU - Huang, Jie

AU - Azmitia, Efrain C.

N1 - Funding Information: This research was supported by the National Institute of Mental Health Grant NIMH-NIH-55250.

PY - 1999/7/23

Y1 - 1999/7/23

N2 - Short-term adrenalectomy induces a loss of mature granular neuronal phenotypes in the hippocampal dentate gyrus; injection of 5-HT1A receptor agonist reverses this effect. Adrenalectomy also induces an increase of expression of 5-HT1A receptor mRNA in the dentate gyrus. This study tested the effect of 5-HT1A agonist on this adrenalectomy-induced increase of 5- HT1A mRNA. Five, 9 and 18 days after adrenalectomy, 5-HT1A receptor mRNA is increased in the granular layer of the dentate gyrus. The increase is nearly 100% at day 18 after adrenalectomy. 5-HT1A agonist treatment decreased 5- HT1A mRNA both at 9 (20%) and 18 days (34%) after adrenalectomy. Our results indicated that a 5-HT1A agonist can partly reverse the adrenalectomy-induced increase of 5-HT1A mRNA and loss of mature granular neuronal phenotypes in hippocampal dentate gyrus.

AB - Short-term adrenalectomy induces a loss of mature granular neuronal phenotypes in the hippocampal dentate gyrus; injection of 5-HT1A receptor agonist reverses this effect. Adrenalectomy also induces an increase of expression of 5-HT1A receptor mRNA in the dentate gyrus. This study tested the effect of 5-HT1A agonist on this adrenalectomy-induced increase of 5- HT1A mRNA. Five, 9 and 18 days after adrenalectomy, 5-HT1A receptor mRNA is increased in the granular layer of the dentate gyrus. The increase is nearly 100% at day 18 after adrenalectomy. 5-HT1A agonist treatment decreased 5- HT1A mRNA both at 9 (20%) and 18 days (34%) after adrenalectomy. Our results indicated that a 5-HT1A agonist can partly reverse the adrenalectomy-induced increase of 5-HT1A mRNA and loss of mature granular neuronal phenotypes in hippocampal dentate gyrus.

KW - Adrenalectomy

KW - In situ hybridization

KW - Ipsapirone

KW - Neuroplasticity

KW - Neurotrophic factor

KW - Serotonin

KW - Steroids

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Homologous regulation of 5-HT1A receptor mRNA in adult rat hippocampal dentate gyrus

Abstract

Keywords

ASJC Scopus subject areas

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