Homology model building of the thyroid transcription factor 1 homeodomain

F. Fogolari; G. Esposito; P. Viglino; G. Damante; A. Pastore

doi:10.1093/protein/6.5.513

Homology model building of the thyroid transcription factor 1 homeodomain

F. Fogolari, G. Esposito, P. Viglino, G. Damante, A. Pastore

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A possible structure for the homeodomain of rat thyroid transcription factor 1 is proposed on the basis of the homology with other homeodomains whose structures have been solved by X-ray crystallography. A structure very similar to the reference ones is feasible and may account for the observed DNA-binding specificity. Structural features of the model, which are likely to be shared by other homeodomains, are discussed and may help researchers in the field to analyse their own experimental data.

Original language	English (US)
Pages (from-to)	513-519
Number of pages	7
Journal	Protein Engineering, Design and Selection
Volume	6
Issue number	5
DOIs	https://doi.org/10.1093/protein/6.5.513
State	Published - Jul 1993

Keywords

3-D structure
Homeodomain
Homology modeling
Transcription factor

ASJC Scopus subject areas

General Medicine

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10.1093/protein/6.5.513

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title = "Homology model building of the thyroid transcription factor 1 homeodomain",

abstract = "A possible structure for the homeodomain of rat thyroid transcription factor 1 is proposed on the basis of the homology with other homeodomains whose structures have been solved by X-ray crystallography. A structure very similar to the reference ones is feasible and may account for the observed DNA-binding specificity. Structural features of the model, which are likely to be shared by other homeodomains, are discussed and may help researchers in the field to analyse their own experimental data.",

keywords = "3-D structure, Homeodomain, Homology modeling, Transcription factor",

author = "F. Fogolari and G. Esposito and P. Viglino and G. Damante and A. Pastore",

note = "Funding Information: We wish to thank T.Gibson and R.Di Lauro for reading the typescript and making useful comments, S.Formisano for useful discussions, and G.Vriend for making available his powerful program WHATIF and for expert support in using it. F.Fogolari was supported by an EMBO fellowship.",

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T1 - Homology model building of the thyroid transcription factor 1 homeodomain

AU - Fogolari, F.

AU - Esposito, G.

AU - Viglino, P.

AU - Damante, G.

AU - Pastore, A.

N1 - Funding Information: We wish to thank T.Gibson and R.Di Lauro for reading the typescript and making useful comments, S.Formisano for useful discussions, and G.Vriend for making available his powerful program WHATIF and for expert support in using it. F.Fogolari was supported by an EMBO fellowship.

PY - 1993/7

Y1 - 1993/7

N2 - A possible structure for the homeodomain of rat thyroid transcription factor 1 is proposed on the basis of the homology with other homeodomains whose structures have been solved by X-ray crystallography. A structure very similar to the reference ones is feasible and may account for the observed DNA-binding specificity. Structural features of the model, which are likely to be shared by other homeodomains, are discussed and may help researchers in the field to analyse their own experimental data.

AB - A possible structure for the homeodomain of rat thyroid transcription factor 1 is proposed on the basis of the homology with other homeodomains whose structures have been solved by X-ray crystallography. A structure very similar to the reference ones is feasible and may account for the observed DNA-binding specificity. Structural features of the model, which are likely to be shared by other homeodomains, are discussed and may help researchers in the field to analyse their own experimental data.

KW - 3-D structure

KW - Homeodomain

KW - Homology modeling

KW - Transcription factor

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Homology model building of the thyroid transcription factor 1 homeodomain

Abstract

Keywords

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