Homology model building of the thyroid transcription factor 1 homeodomain

F. Fogolari, G. Esposito, P. Viglino, G. Damante, A. Pastore

Research output: Contribution to journalArticlepeer-review


A possible structure for the homeodomain of rat thyroid transcription factor 1 is proposed on the basis of the homology with other homeodomains whose structures have been solved by X-ray crystallography. A structure very similar to the reference ones is feasible and may account for the observed DNA-binding specificity. Structural features of the model, which are likely to be shared by other homeodomains, are discussed and may help researchers in the field to analyse their own experimental data.

Original languageEnglish (US)
Pages (from-to)513-519
Number of pages7
JournalProtein Engineering, Design and Selection
Issue number5
StatePublished - Jul 1993


  • 3-D structure
  • Homeodomain
  • Homology modeling
  • Transcription factor

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Molecular Biology


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