TY - JOUR
T1 - How can nanotechnology help the fight against breast cancer?
AU - Avitabile, Elisabetta
AU - Bedognetti, Davide
AU - Ciofani, Gianni
AU - Bianco, Alberto
AU - Delogu, Lucia Gemma
N1 - Publisher Copyright:
© 2018 The Royal Society of Chemistry.
PY - 2018/7/7
Y1 - 2018/7/7
N2 - In this review we provide a broad overview on the use of nanotechnology for the fight against breast cancer (BC). Nowadays, detection, diagnosis, treatment, and prevention may be possible thanks to the application of nanotechnology to clinical practice. Taking into consideration the different forms of BC and the disease status, nanomaterials can be designed to meet the most forefront objectives of modern therapy and diagnosis. We have analyzed in detail three main groups of nanomaterial applications for BC treatment and diagnosis. We have identified several types of drugs successfully conjugated with nanomaterials. We have analyzed the main important imaging techniques and all nanomaterials used to help the non-invasive, early detection of the lesions. Moreover, we have examined theranostic nanomaterials as unique tools, combining imaging, detection, and therapy for BC. This state of the art review provides a useful guide depicting how nanotechnology can be used to overcome the current barriers in BC clinical practice, and how it will shape the future scenario of treatments, prevention, and diagnosis, revolutionizing the current approaches, e.g., reducing the suffering related to chemotherapy.
AB - In this review we provide a broad overview on the use of nanotechnology for the fight against breast cancer (BC). Nowadays, detection, diagnosis, treatment, and prevention may be possible thanks to the application of nanotechnology to clinical practice. Taking into consideration the different forms of BC and the disease status, nanomaterials can be designed to meet the most forefront objectives of modern therapy and diagnosis. We have analyzed in detail three main groups of nanomaterial applications for BC treatment and diagnosis. We have identified several types of drugs successfully conjugated with nanomaterials. We have analyzed the main important imaging techniques and all nanomaterials used to help the non-invasive, early detection of the lesions. Moreover, we have examined theranostic nanomaterials as unique tools, combining imaging, detection, and therapy for BC. This state of the art review provides a useful guide depicting how nanotechnology can be used to overcome the current barriers in BC clinical practice, and how it will shape the future scenario of treatments, prevention, and diagnosis, revolutionizing the current approaches, e.g., reducing the suffering related to chemotherapy.
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UR - http://www.scopus.com/inward/citedby.url?scp=85049508144&partnerID=8YFLogxK
U2 - 10.1039/c8nr02796j
DO - 10.1039/c8nr02796j
M3 - Review article
C2 - 29917035
AN - SCOPUS:85049508144
SN - 2040-3364
VL - 10
SP - 11719
EP - 11731
JO - Nanoscale
JF - Nanoscale
IS - 25
ER -