Abstract
Hsp90 reveals phenotypic variation in the laboratory, but is Hsp90 depletion important in the wild? Recent work from Chen and Wagner in BMC Evolutionary Biology has discovered a naturally occurring Drosophila allele that downregulates Hsp90, creating sensitivity to cryptic genetic variation. Laboratory studies suggest that the exact magnitude of Hsp90 downregulation is important. Extreme Hsp90 depletion might reactivate transposable elements and/or induce aneuploidy, in addition to revealing cryptic genetic variation.See research article http://wwww.biomedcentral.com/1471-2148/12/25.
Original language | English (US) |
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Article number | 14 |
Journal | BMC Biology |
Volume | 10 |
DOIs |
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State | Published - Feb 27 2012 |
ASJC Scopus subject areas
- Biotechnology
- Structural Biology
- Ecology, Evolution, Behavior and Systematics
- Physiology
- General Biochemistry, Genetics and Molecular Biology
- General Agricultural and Biological Sciences
- Plant Science
- Developmental Biology
- Cell Biology