Human cells and networks of pain: Transforming pain target identification and therapeutic development

William Renthal; Alexander Chamessian; Michele Curatolo; Steve Davidson; Michael Burton; Sulayman Dib-Hajj; Patrick M. Dougherty; Allison D. Ebert; Robert W. Gereau; Andre Ghetti; Michael S. Gold; Gwendolyn Hoben; Daniela Maria Menichella; Philippe Mercier; Wilson Z. Ray; Daniela Salvemini; Rebecca P. Seal; Stephen Waxman; Clifford J. Woolf; Cheryl L. Stucky; Theodore J. Price

doi:10.1016/j.neuron.2021.04.005

Human cells and networks of pain: Transforming pain target identification and therapeutic development

William Renthal, Alexander Chamessian, Michele Curatolo, Steve Davidson, Michael Burton, Sulayman Dib-Hajj, Patrick M. Dougherty, Allison D. Ebert, Robert W. Gereau, Andre Ghetti, Michael S. Gold, Gwendolyn Hoben, Daniela Maria Menichella, Philippe Mercier, Wilson Z. Ray, Daniela Salvemini, Rebecca P. Seal, Stephen Waxman, Clifford J. Woolf, Cheryl L. StuckyTheodore J. Price

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

Chronic pain is a disabling disease with limited treatment options. While animal models have revealed important aspects of pain neurobiology, therapeutic translation of this knowledge requires our understanding of these cells and networks of pain in humans. We propose a multi-institutional collaboration to rigorously and ethically address this challenge.

Original language	English (US)
Pages (from-to)	1426-1429
Number of pages	4
Journal	Neuron
Volume	109
Issue number	9
DOIs	https://doi.org/10.1016/j.neuron.2021.04.005
State	Published - May 5 2021

ASJC Scopus subject areas

General Neuroscience

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Renthal, W., Chamessian, A., Curatolo, M., Davidson, S., Burton, M., Dib-Hajj, S., Dougherty, P. M., Ebert, A. D., Gereau, R. W., Ghetti, A., Gold, M. S., Hoben, G., Menichella, D. M., Mercier, P., Ray, W. Z., Salvemini, D., Seal, R. P., Waxman, S., Woolf, C. J., ... Price, T. J. (2021). Human cells and networks of pain: Transforming pain target identification and therapeutic development. Neuron, 109(9), 1426-1429. https://doi.org/10.1016/j.neuron.2021.04.005

Renthal, W, Chamessian, A, Curatolo, M, Davidson, S, Burton, M, Dib-Hajj, S, Dougherty, PM, Ebert, AD, Gereau, RW, Ghetti, A, Gold, MS, Hoben, G, Menichella, DM, Mercier, P, Ray, WZ, Salvemini, D, Seal, RP, Waxman, S, Woolf, CJ, Stucky, CL & Price, TJ 2021, 'Human cells and networks of pain: Transforming pain target identification and therapeutic development', Neuron, vol. 109, no. 9, pp. 1426-1429. https://doi.org/10.1016/j.neuron.2021.04.005

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abstract = "Chronic pain is a disabling disease with limited treatment options. While animal models have revealed important aspects of pain neurobiology, therapeutic translation of this knowledge requires our understanding of these cells and networks of pain in humans. We propose a multi-institutional collaboration to rigorously and ethically address this challenge.",

author = "William Renthal and Alexander Chamessian and Michele Curatolo and Steve Davidson and Michael Burton and Sulayman Dib-Hajj and Dougherty, {Patrick M.} and Ebert, {Allison D.} and Gereau, {Robert W.} and Andre Ghetti and Gold, {Michael S.} and Gwendolyn Hoben and Menichella, {Daniela Maria} and Philippe Mercier and Ray, {Wilson Z.} and Daniela Salvemini and Seal, {Rebecca P.} and Stephen Waxman and Woolf, {Clifford J.} and Stucky, {Cheryl L.} and Price, {Theodore J.}",

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AU - Renthal, William

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AU - Burton, Michael

AU - Dib-Hajj, Sulayman

AU - Dougherty, Patrick M.

AU - Ebert, Allison D.

AU - Gereau, Robert W.

AU - Ghetti, Andre

AU - Gold, Michael S.

AU - Hoben, Gwendolyn

AU - Menichella, Daniela Maria

AU - Mercier, Philippe

AU - Ray, Wilson Z.

AU - Salvemini, Daniela

AU - Seal, Rebecca P.

AU - Waxman, Stephen

AU - Woolf, Clifford J.

AU - Stucky, Cheryl L.

AU - Price, Theodore J.

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Human cells and networks of pain: Transforming pain target identification and therapeutic development

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