Human Milk Bacterial and Glycosylation Patterns Differ by Delivery Mode

Marina Hoashi; Lawrence Meche; Lara K. Mahal; Elizabeth Bakacs; Deanna Nardella; Frederick Naftolin; Naomi Bar-Yam; Maria G. Dominguez-Bello

doi:10.1177/1933719115623645

Human Milk Bacterial and Glycosylation Patterns Differ by Delivery Mode

Marina Hoashi, Lawrence Meche, Lara K. Mahal, Elizabeth Bakacs, Deanna Nardella, Frederick Naftolin, Naomi Bar-Yam, Maria G. Dominguez-Bello

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Mammals have evolved to nourish their offspring exclusively with maternal milk for around half of the lactation period, a crucial developmental window. In view of oral-breast contact during lactation and the differences in oral microbiota between cesarean section (C-section) and vaginally delivered infants, we expected differences in milk composition by delivery mode. We performed a cross-sectional study of banked human milk and found changes related to time since delivery in bacterial abundance and glycosylation patterns only in milk from women who delivered vaginally. The results warrant further research into the effects of delivery mode on milk microbes, milk glycosylation, and postpartum infant development.

Original language	English (US)
Pages (from-to)	902-907
Number of pages	6
Journal	Reproductive Sciences
Volume	23
Issue number	7
DOIs	https://doi.org/10.1177/1933719115623645
State	Published - Jul 1 2016

Keywords

C-section
breast milk
human microbiome
milk glycosylation

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1177/1933719115623645

Cite this

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abstract = "Mammals have evolved to nourish their offspring exclusively with maternal milk for around half of the lactation period, a crucial developmental window. In view of oral-breast contact during lactation and the differences in oral microbiota between cesarean section (C-section) and vaginally delivered infants, we expected differences in milk composition by delivery mode. We performed a cross-sectional study of banked human milk and found changes related to time since delivery in bacterial abundance and glycosylation patterns only in milk from women who delivered vaginally. The results warrant further research into the effects of delivery mode on milk microbes, milk glycosylation, and postpartum infant development.",

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AU - Hoashi, Marina

AU - Meche, Lawrence

AU - Mahal, Lara K.

AU - Bakacs, Elizabeth

AU - Nardella, Deanna

AU - Naftolin, Frederick

AU - Bar-Yam, Naomi

AU - Dominguez-Bello, Maria G.

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AB - Mammals have evolved to nourish their offspring exclusively with maternal milk for around half of the lactation period, a crucial developmental window. In view of oral-breast contact during lactation and the differences in oral microbiota between cesarean section (C-section) and vaginally delivered infants, we expected differences in milk composition by delivery mode. We performed a cross-sectional study of banked human milk and found changes related to time since delivery in bacterial abundance and glycosylation patterns only in milk from women who delivered vaginally. The results warrant further research into the effects of delivery mode on milk microbes, milk glycosylation, and postpartum infant development.

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Human Milk Bacterial and Glycosylation Patterns Differ by Delivery Mode

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Keywords

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