Human milk hyaluronan enhances innate defense of the intestinal epithelium

David R. Hill; Hyunjin K. Rho; Sean P. Kessler; Ripal Amin; Craig R. Homer; Christine McDonald; Mary K. Cowman; Carol A. De La Motte

doi:10.1074/jbc.M113.468629

Human milk hyaluronan enhances innate defense of the intestinal epithelium

David R. Hill, Hyunjin K. Rho, Sean P. Kessler, Ripal Amin, Craig R. Homer, Christine McDonald, Mary K. Cowman, Carol A. De La Motte

Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Background:Human milk contains hyaluronan (HA). Results:Milk HA concentration is highest immediately after delivery. Treatment of epithelium with physiologic levels of milk-derived HA increases intracellular expression of-defensin (in vitroandin vivo) and resistance toSalmonella. Conclusion:Milk HA enhances functional antimicrobial defense mechanisms of the intestinal epithelium. Significance:Milk HA may be a mediator of maternal protection of newborns.

Original language	English (US)
Pages (from-to)	29090-29104
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	288
Issue number	40
DOIs	https://doi.org/10.1074/jbc.M113.468629
State	Published - Oct 4 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.468629

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title = "Human milk hyaluronan enhances innate defense of the intestinal epithelium",

abstract = "Background:Human milk contains hyaluronan (HA). Results:Milk HA concentration is highest immediately after delivery. Treatment of epithelium with physiologic levels of milk-derived HA increases intracellular expression of-defensin (in vitroandin vivo) and resistance toSalmonella. Conclusion:Milk HA enhances functional antimicrobial defense mechanisms of the intestinal epithelium. Significance:Milk HA may be a mediator of maternal protection of newborns.",

author = "Hill, {David R.} and Rho, {Hyunjin K.} and Kessler, {Sean P.} and Ripal Amin and Homer, {Craig R.} and Christine McDonald and Cowman, {Mary K.} and {De La Motte}, {Carol A.}",

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AU - Hill, David R.

AU - Rho, Hyunjin K.

AU - Kessler, Sean P.

AU - Amin, Ripal

AU - Homer, Craig R.

AU - McDonald, Christine

AU - Cowman, Mary K.

AU - De La Motte, Carol A.

PY - 2013/10/4

Y1 - 2013/10/4

N2 - Background:Human milk contains hyaluronan (HA). Results:Milk HA concentration is highest immediately after delivery. Treatment of epithelium with physiologic levels of milk-derived HA increases intracellular expression of-defensin (in vitroandin vivo) and resistance toSalmonella. Conclusion:Milk HA enhances functional antimicrobial defense mechanisms of the intestinal epithelium. Significance:Milk HA may be a mediator of maternal protection of newborns.

AB - Background:Human milk contains hyaluronan (HA). Results:Milk HA concentration is highest immediately after delivery. Treatment of epithelium with physiologic levels of milk-derived HA increases intracellular expression of-defensin (in vitroandin vivo) and resistance toSalmonella. Conclusion:Milk HA enhances functional antimicrobial defense mechanisms of the intestinal epithelium. Significance:Milk HA may be a mediator of maternal protection of newborns.

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 40

ER -

Human milk hyaluronan enhances innate defense of the intestinal epithelium

Abstract

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