Human milk hyaluronan enhances innate defense of the intestinal epithelium

David R. Hill, Hyunjin K. Rho, Sean P. Kessler, Ripal Amin, Craig R. Homer, Christine McDonald, Mary K. Cowman, Carol A. De La Motte

Research output: Contribution to journalArticle

Abstract

Background:Human milk contains hyaluronan (HA). Results:Milk HA concentration is highest immediately after delivery. Treatment of epithelium with physiologic levels of milk-derived HA increases intracellular expression of-defensin (in vitroandin vivo) and resistance toSalmonella. Conclusion:Milk HA enhances functional antimicrobial defense mechanisms of the intestinal epithelium. Significance:Milk HA may be a mediator of maternal protection of newborns.

Original languageEnglish (US)
Pages (from-to)29090-29104
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
StatePublished - Oct 4 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Hill, D. R., Rho, H. K., Kessler, S. P., Amin, R., Homer, C. R., McDonald, C., Cowman, M. K., & De La Motte, C. A. (2013). Human milk hyaluronan enhances innate defense of the intestinal epithelium. Journal of Biological Chemistry, 288(40), 29090-29104. https://doi.org/10.1074/jbc.M113.468629