Human population studies and nutritional intervention

Yu Chen, Fen Wu

Research output: Chapter in Book/Report/Conference proceedingChapter


There is wide variation in the susceptibility to arsenic toxicity, and nutrition is believed to be an important susceptibility factor. This chapter discusses epidemiologic data on the various nutritional factors that influence arsenic metabolism in humans and nutritional factors in relation to arsenic-induced health effects. It describes epidemiologic studies on nutritional factors that influence the one-carbon metabolism. One of the strongest studies to date on the impact of nutritional status on risk for arsenic-induced health effects is the recent case-control study of 177 urothelial carcinoma cases and 488 controls in a population in Taiwan exposed to low concentrations of arsenic in drinking water. Particular attention should be given to the cardiovascular effects under various exposure scenarios, especially in low-income countries such as South Asia, where the populations are undergoing an epidemiologic transition in which the burden of CVD is increasing. The use of food-frequency questionnaire (FFQ) introduced inevitable measurement errors.

Original languageEnglish (US)
Title of host publicationArsenic
Subtitle of host publicationExposure Sources, Health Risks, and Mechanisms of Toxicity
Number of pages16
ISBN (Electronic)9781118876992
ISBN (Print)9781118511145
StatePublished - Oct 30 2015


  • Arsenic metabolism
  • Arsenic-induced health effects
  • Cardiovascular effects
  • Epidemiologic studies
  • Food-frequency questionnaire
  • Nutritional intervention
  • One-carbon metabolism
  • Urothelial carcinoma

ASJC Scopus subject areas

  • General Chemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • General Engineering
  • General Medicine


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