Hyaluronidase activity during open wound healing in rabbits: A preliminary report

Charles N. Bertolami, R. Bruce Donoff

Research output: Contribution to journalArticlepeer-review

Abstract

The presence of an enzyme with hyaluronidase activity has been established for open wound granulation tissue in rabbits. Such activity was unrelated to the presence of inflammatory cells and, in fact, was absent in early wounds. Activity increased 7 days after wounding and remained elevated through the 19-day term of the study. The approximate hyaluronic acid content of granulation tissue during healing decreased markedly during this period. The relationship of hyaluronidase to hyaluronic acid in the process of open would healing is discussed.

Original languageEnglish (US)
Pages (from-to)256-259
Number of pages4
JournalJournal of Surgical Research
Volume25
Issue number3
DOIs
StatePublished - Sep 1978

ASJC Scopus subject areas

  • Surgery

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