TY - JOUR
T1 - Hyaluronidase activity during open wound healing in rabbits
T2 - A preliminary report
AU - Bertolami, Charles N.
AU - Donoff, R. Bruce
N1 - Funding Information:
1 Supported by General Biomedical Research Support Grant to Massachusetts General Hospital and Burns Center Grant to Shriners’ Bums Institute. * Recipient of American Society of Oral Surgeons Research Fellowship. 3 Reprint requests should be sent to R. Bruce Donoff, D.M.D., M.D., Department of Oral Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114.
PY - 1978/9
Y1 - 1978/9
N2 - The presence of an enzyme with hyaluronidase activity has been established for open wound granulation tissue in rabbits. Such activity was unrelated to the presence of inflammatory cells and, in fact, was absent in early wounds. Activity increased 7 days after wounding and remained elevated through the 19-day term of the study. The approximate hyaluronic acid content of granulation tissue during healing decreased markedly during this period. The relationship of hyaluronidase to hyaluronic acid in the process of open would healing is discussed.
AB - The presence of an enzyme with hyaluronidase activity has been established for open wound granulation tissue in rabbits. Such activity was unrelated to the presence of inflammatory cells and, in fact, was absent in early wounds. Activity increased 7 days after wounding and remained elevated through the 19-day term of the study. The approximate hyaluronic acid content of granulation tissue during healing decreased markedly during this period. The relationship of hyaluronidase to hyaluronic acid in the process of open would healing is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0018128997&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018128997&partnerID=8YFLogxK
U2 - 10.1016/0022-4804(78)90116-6
DO - 10.1016/0022-4804(78)90116-6
M3 - Article
C2 - 703304
AN - SCOPUS:0018128997
SN - 0022-4804
VL - 25
SP - 256
EP - 259
JO - Journal of Surgical Research
JF - Journal of Surgical Research
IS - 3
ER -