Hybrid Diphenylalkyne-Dipeptide Oligomers Induce Multistrand β-Sheet Formation

Jonathan E. Ross; Peter C. Knipe; Sam Thompson; Andrew D. Hamilton

doi:10.1002/chem.201502690

Hybrid Diphenylalkyne-Dipeptide Oligomers Induce Multistrand β-Sheet Formation

Jonathan E. Ross, Peter C. Knipe, Sam Thompson, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Functionalized diphenylalkynes provide a template for the presentation of protein-like surfaces composed of multistrand β-sheets. The conformational properties of three-, four-, and seven-stranded systems have been investigated in the solid- and solution-state. This class of molecule may be suitable for the mediation of therapeutically relevant protein-protein interactions. β-Sheets: Functionalized diphenylalkynes provide a template for the presentation of protein-like surfaces composed of multi-strand β-sheets. The conformational properties of three-, four-, and seven-stranded systems have been investigated in the solid- and solution-state. This class of molecule may be suitable for the mediation of therapeutically relevant protein-protein interactions.

Original language	English (US)
Pages (from-to)	13518-13521
Number of pages	4
Journal	Chemistry - A European Journal
Volume	21
Issue number	39
DOIs	https://doi.org/10.1002/chem.201502690
State	Published - Sep 1 2015

Keywords

foldamer
peptidomimetics
protein surface
protein-protein interaction
secondary structure
β-sheet

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1002/chem.201502690

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title = "Hybrid Diphenylalkyne-Dipeptide Oligomers Induce Multistrand β-Sheet Formation",

abstract = "Functionalized diphenylalkynes provide a template for the presentation of protein-like surfaces composed of multistrand β-sheets. The conformational properties of three-, four-, and seven-stranded systems have been investigated in the solid- and solution-state. This class of molecule may be suitable for the mediation of therapeutically relevant protein-protein interactions. β-Sheets: Functionalized diphenylalkynes provide a template for the presentation of protein-like surfaces composed of multi-strand β-sheets. The conformational properties of three-, four-, and seven-stranded systems have been investigated in the solid- and solution-state. This class of molecule may be suitable for the mediation of therapeutically relevant protein-protein interactions.",

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AU - Ross, Jonathan E.

AU - Knipe, Peter C.

AU - Thompson, Sam

AU - Hamilton, Andrew D.

PY - 2015/9/1

Y1 - 2015/9/1

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KW - foldamer

KW - peptidomimetics

KW - protein surface

KW - protein-protein interaction

KW - secondary structure

KW - β-sheet

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Hybrid Diphenylalkyne-Dipeptide Oligomers Induce Multistrand β-Sheet Formation

Abstract

Keywords

ASJC Scopus subject areas

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