Hybridization-sensitive fluorescence control in the near-infrared wavelength range

Shuji Ikeda, Hiroyuki Yanagisawa, Akiko Nakamura, Dan Ohtan Wang, Mizue Yuki, Akimitsu Okamoto

Research output: Contribution to journalArticlepeer-review


A series of near-infrared fluorescent probes were designed based on the concept of emission control caused by interdye excitonic interaction. The fluorescent probes showed very weak emission in the unhybridized state, whereas they emitted near-infrared fluorescence after hybridization with the complementary nucleic acid. The hybridization-dependent switching of fluorescence emission made it possible to monitor mRNA in human cells in the range of near-infrared wavelengths.

Original languageEnglish (US)
Pages (from-to)4199-4204
Number of pages6
JournalOrganic and Biomolecular Chemistry
Issue number11
StatePublished - Jun 7 2011

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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