Hybridization-sensitive fluorescence control in the near-infrared wavelength range

Shuji Ikeda; Hiroyuki Yanagisawa; Akiko Nakamura; Dan Ohtan Wang; Mizue Yuki; Akimitsu Okamoto

doi:10.1039/c1ob05252g

Hybridization-sensitive fluorescence control in the near-infrared wavelength range

Shuji Ikeda, Hiroyuki Yanagisawa, Akiko Nakamura, Dan Ohtan Wang, Mizue Yuki, Akimitsu Okamoto

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

A series of near-infrared fluorescent probes were designed based on the concept of emission control caused by interdye excitonic interaction. The fluorescent probes showed very weak emission in the unhybridized state, whereas they emitted near-infrared fluorescence after hybridization with the complementary nucleic acid. The hybridization-dependent switching of fluorescence emission made it possible to monitor mRNA in human cells in the range of near-infrared wavelengths.

Original language	English (US)
Pages (from-to)	4199-4204
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	11
DOIs	https://doi.org/10.1039/c1ob05252g
State	Published - Jun 7 2011

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c1ob05252g

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abstract = "A series of near-infrared fluorescent probes were designed based on the concept of emission control caused by interdye excitonic interaction. The fluorescent probes showed very weak emission in the unhybridized state, whereas they emitted near-infrared fluorescence after hybridization with the complementary nucleic acid. The hybridization-dependent switching of fluorescence emission made it possible to monitor mRNA in human cells in the range of near-infrared wavelengths.",

author = "Shuji Ikeda and Hiroyuki Yanagisawa and Akiko Nakamura and Wang, {Dan Ohtan} and Mizue Yuki and Akimitsu Okamoto",

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AU - Ikeda, Shuji

AU - Yanagisawa, Hiroyuki

AU - Nakamura, Akiko

AU - Wang, Dan Ohtan

AU - Yuki, Mizue

AU - Okamoto, Akimitsu

PY - 2011/6/7

Y1 - 2011/6/7

N2 - A series of near-infrared fluorescent probes were designed based on the concept of emission control caused by interdye excitonic interaction. The fluorescent probes showed very weak emission in the unhybridized state, whereas they emitted near-infrared fluorescence after hybridization with the complementary nucleic acid. The hybridization-dependent switching of fluorescence emission made it possible to monitor mRNA in human cells in the range of near-infrared wavelengths.

AB - A series of near-infrared fluorescent probes were designed based on the concept of emission control caused by interdye excitonic interaction. The fluorescent probes showed very weak emission in the unhybridized state, whereas they emitted near-infrared fluorescence after hybridization with the complementary nucleic acid. The hybridization-dependent switching of fluorescence emission made it possible to monitor mRNA in human cells in the range of near-infrared wavelengths.

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Hybridization-sensitive fluorescence control in the near-infrared wavelength range

Abstract

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