Hydrogel formation between enantiomeric B-A-B-type block copolymers of polylactides (PLLA or PDLA: A) and polyoxyethylene (PEG: B); PEG-PLLA-PEG and PEG-PDLA-PEG

Takashi Mukose, Tomoko Fujiwara, Junko Nakano, Ikuo Taniguchi, Masatoshi Miyamoto, Yoshiharu Kimura, Iwao Teraoka, Chan Woo Lee

Research output: Contribution to journalArticlepeer-review

Abstract

A mixed suspension of the enantiomeric B-A-B triblock copolymers, polyoxyethylene-block-poly(L-lactide)-block-polyoxyethylene (PEG-PLLA-PEG) and poly-oxyethylene-block-poly(D-lactide)-block-polyoxyethylene (PEG-PDLA-PEG), was found to induce reversible gel-to-sol transition depending on the polymer concentration and temperature. The storage and loss moduli of the gel formed at lower temperature were much higher than those of the gel prepared from the corresponding ABA-type triblock copolymers because of the higher polymer concentration in the former. Although the stereo-complexation of the PLLA and PDLA blocks occurred at higher temperature also in the B-A-B copolymers, it was not responsible for the gelation of the mixed suspension. The PEG chains, involved in the helix formation of the PLLA and PDLA, should form helices with opposite helical senses to aggregate and lead the gelation of the system.

Original languageEnglish (US)
Pages (from-to)361-367
Number of pages7
JournalMacromolecular Bioscience
Volume4
Issue number3
DOIs
StatePublished - Mar 15 2004

Keywords

  • Block copolymers
  • Hydrogels
  • Poly(ethylene glycol)
  • Polylactides
  • Stereo-complex

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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