Hyperpolarization of amino acid precursors to neurotransmitters with parahydrogen induced polarization

Pei Che Soon; Xiang Xu; Boyang Zhang; Francesca Gruppi; James W. Canary; Alexej Jerschow

doi:10.1039/c3cc40426a

Hyperpolarization of amino acid precursors to neurotransmitters with parahydrogen induced polarization

Pei Che Soon, Xiang Xu, Boyang Zhang, Francesca Gruppi, James W. Canary, Alexej Jerschow

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Several important neurotransmitter precursors were hyperpolarized via homogeneous hydrogenation with parahydrogen. Polarization enhancement was achieved for ¹H and ¹³C spins by several orders of magnitude compared to thermal spectra. Such large signal enhancements of these molecules could facilitate neurotransmitter studies.

Original language	English (US)
Pages (from-to)	5304-5306
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	46
DOIs	https://doi.org/10.1039/c3cc40426a
State	Published - May 14 2013

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c3cc40426a

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title = "Hyperpolarization of amino acid precursors to neurotransmitters with parahydrogen induced polarization",

abstract = "Several important neurotransmitter precursors were hyperpolarized via homogeneous hydrogenation with parahydrogen. Polarization enhancement was achieved for 1H and 13C spins by several orders of magnitude compared to thermal spectra. Such large signal enhancements of these molecules could facilitate neurotransmitter studies.",

author = "Soon, {Pei Che} and Xiang Xu and Boyang Zhang and Francesca Gruppi and Canary, {James W.} and Alexej Jerschow",

year = "2013",

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doi = "10.1039/c3cc40426a",

language = "English (US)",

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AU - Soon, Pei Che

AU - Xu, Xiang

AU - Zhang, Boyang

AU - Gruppi, Francesca

AU - Canary, James W.

AU - Jerschow, Alexej

PY - 2013/5/14

Y1 - 2013/5/14

N2 - Several important neurotransmitter precursors were hyperpolarized via homogeneous hydrogenation with parahydrogen. Polarization enhancement was achieved for 1H and 13C spins by several orders of magnitude compared to thermal spectra. Such large signal enhancements of these molecules could facilitate neurotransmitter studies.

AB - Several important neurotransmitter precursors were hyperpolarized via homogeneous hydrogenation with parahydrogen. Polarization enhancement was achieved for 1H and 13C spins by several orders of magnitude compared to thermal spectra. Such large signal enhancements of these molecules could facilitate neurotransmitter studies.

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EP - 5306

JO - Chemical Communications

JF - Chemical Communications

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ER -

Hyperpolarization of amino acid precursors to neurotransmitters with parahydrogen induced polarization

Abstract

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