@article{c5cc574dffc54dedb5612d304b06fd42,
title = "Identification and characterization of a supraclavicular brown adipose tissue in mice",
abstract = "A fundamental challenge to our understanding of brown adipose tissue (BAT) is the lack of an animal model that faithfully represents human BAT. Such a model is essential for direct assessment of the function and therapeutic potential of BAT depots in humans. In human adults, most of the thermoactive BAT depots are located in the supraclavicular region of the neck, while mouse studies focus on depots located in the interscapular region of the torso. We recently discovered BAT depots that are located in a region analogous to that of human supraclavicular BAT (scBAT). Here, we report that the mouse scBAT depot has morphological characteristics of classical BAT, possesses the potential for high thermogenic activity, and expresses a gene signature that is similar to that of human scBAT. Taken together, our studies reveal a mouse BAT depot that represents human BAT and provides a unique tool for developing new translatable approaches for utilizing human scBAT.",
author = "Qianxing Mo and Jordan Salley and Tony Roshan and Baer, {Lisa A.} and May, {Francis J.} and Jaehnig, {Eric J.} and Lehnig, {Adam C.} and Xin Guo and Qiang Tong and Nuotio-Antar, {Alli M.} and Farnaz Shamsi and Tseng, {Yu Hua} and Stanford, {Kristin I.} and Chen, {Miao Hsueh}",
note = "Funding Information: The authors wish to thank Yuxiang Sun for useful advice and Chitra Jeyasankar for technical support. This study was supported by USDA/ARS CRIS 3092-5-001-059, NIH P30-DK079638, and American Heart Association 16GRNT30720003 to MHC; and NIH K01-DK105109 to KIS. RNA sequencing and data analyses were supported in part by the Genomic and RNA Profiling Core at BCM with funding from the NIH Center grant (P30-DK079638). TEM analyses were supported by the Integrated Microscopy Core at BCM with funding from the NIH (HD007495, DK56338, and CA125123). Publisher Copyright: {\textcopyright} 2017 American Society for Clinical Investigation. All rights reserved.",
year = "2017",
month = jun,
day = "2",
doi = "10.1172/jci.insight.93166",
language = "English (US)",
volume = "2",
journal = "JCI insight",
issn = "2379-3708",
publisher = "The American Society for Clinical Investigation",
number = "11",
}