Identification of a novel HLA-A allele, HLA-A01:195, in a UAE national

Wael Abdrabou; Ini Isabée Witzel; Agnieszka Paduch; Guan Tay; Habiba Alsafar

doi:10.1016/j.humimm.2016.05.010

Identification of a novel HLA-A allele, HLA-A01:195, in a UAE national

Wael Abdrabou, Ini Isabée Witzel, Agnieszka Paduch, Guan Tay, Habiba Alsafar

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Abstract

A novel human leucocyte antigen (HLA)-A allele, HLA-A01:195, was identified by sequence-based typing (SBT) in a UAE national subject. The novel allele is identical to its closest known allele, HLA-A01:01:01:01, in exon 2, 3 and 4, except for a single nucleotide mutation of A to G at position 442 in exon 3 (codon 124 in the α2 domain of the α chain of the mature protein). This A to G mutation results in an amino acid change of isoleucine #124 to valine.

Original language	English (US)
Pages (from-to)	605-608
Number of pages	4
Journal	Human Immunology
Volume	77
Issue number	7
DOIs	https://doi.org/10.1016/j.humimm.2016.05.010
State	Published - Jul 1 2016

Keywords

Arab genetics
HLA-A01:195
Novel HLA-A allele
Sequence based typing

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.humimm.2016.05.010

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title = "Identification of a novel HLA-A allele, HLA-A01:195, in a UAE national",

abstract = "A novel human leucocyte antigen (HLA)-A allele, HLA-A01:195, was identified by sequence-based typing (SBT) in a UAE national subject. The novel allele is identical to its closest known allele, HLA-A01:01:01:01, in exon 2, 3 and 4, except for a single nucleotide mutation of A to G at position 442 in exon 3 (codon 124 in the α2 domain of the α chain of the mature protein). This A to G mutation results in an amino acid change of isoleucine #124 to valine.",

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author = "Wael Abdrabou and Witzel, {Ini Isab{\'e}e} and Agnieszka Paduch and Guan Tay and Habiba Alsafar",

note = "Publisher Copyright: {\textcopyright} 2016 American Society for Histocompatibility and Immunogenetics",

year = "2016",

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T1 - Identification of a novel HLA-A allele, HLA-A01:195, in a UAE national

AU - Abdrabou, Wael

AU - Witzel, Ini Isabée

AU - Paduch, Agnieszka

AU - Tay, Guan

AU - Alsafar, Habiba

PY - 2016/7/1

Y1 - 2016/7/1

N2 - A novel human leucocyte antigen (HLA)-A allele, HLA-A01:195, was identified by sequence-based typing (SBT) in a UAE national subject. The novel allele is identical to its closest known allele, HLA-A01:01:01:01, in exon 2, 3 and 4, except for a single nucleotide mutation of A to G at position 442 in exon 3 (codon 124 in the α2 domain of the α chain of the mature protein). This A to G mutation results in an amino acid change of isoleucine #124 to valine.

AB - A novel human leucocyte antigen (HLA)-A allele, HLA-A01:195, was identified by sequence-based typing (SBT) in a UAE national subject. The novel allele is identical to its closest known allele, HLA-A01:01:01:01, in exon 2, 3 and 4, except for a single nucleotide mutation of A to G at position 442 in exon 3 (codon 124 in the α2 domain of the α chain of the mature protein). This A to G mutation results in an amino acid change of isoleucine #124 to valine.

KW - Arab genetics

KW - HLA-A01:195

KW - Novel HLA-A allele

KW - Sequence based typing

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JO - Human Immunology

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Identification of a novel HLA-A allele, HLA-A01:195, in a UAE national

Abstract

Keywords

ASJC Scopus subject areas

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