Idiomatic (gene) expressions

Research output: Contribution to journalArticlepeer-review


Hidden among the myriad nucleotide variants that constitute each species' gene pool are a few variants that contribute to phenotypic variation. Many of these differences that make a difference are non-coding cisregulatory variants, which, unlike coding variants, can only be identified through laborious experimental analysis. Recently, Cowles et al. described a screening method that does an end-run around this problem by searching for genes whose cis regulation varies without having to find the polymorphic nucleotides that influence transcription. While we will continue to require a diverse arsenal of experimental methods, this versatile method will speed the identification of functional genetic variation.

Original languageEnglish (US)
Pages (from-to)421-424
Number of pages4
Issue number5
StatePublished - May 1 2003

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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