IGF-1 and bone: New discoveries from mouse models

Shoshana Yakar, Hayden William Courtland, David Clemmons

Research output: Contribution to journalReview article

Abstract

Insulin-like growth factor-1 (IGF-1) plays a central role in cellular growth, differentiation, survival, and cell cycle progression. It is expressed early during development and its effects are mediated through binding to a tyrosine kinase receptor, the insulin-like growth factor-1 receptor (IGF-1R). In the circulation, the IGFs bind to IGF-binding proteins (IGFBPs), which determine their bioavailability and regulate the interaction between the IGFs and IGF-1R. Studies in animal models and in humans have established critical roles for IGFs in skeletal growth and development. In this review we present new and old findings from mouse models of the IGF system and discuss their clinical relevance to normal and pathological skeletal physiology.

Original languageEnglish (US)
Pages (from-to)2543-2552
Number of pages10
JournalJournal of Bone and Mineral Research
Volume25
Issue number12
DOIs
StatePublished - Dec 2010

Keywords

  • Bone Accrual
  • Cortical-Bone
  • Growth Hormone
  • Insulin-Like Growth Factor
  • Skeletal Growth

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

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