Imaging in biological tissues by means of diffraction tomography with photon density waves

Andreas H. Hielscher; Frank K. Tittel; Steven L. Jacques

doi:10.1117/12.200865

Imaging in biological tissues by means of diffraction tomography with photon density waves

Andreas H. Hielscher, Frank K. Tittel, Steven L. Jacques

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In biological tissues it is possible to generate photon density waves with wavelength below 5 cm. When these kind of waves encounter optical inhomogeneities with diameters in the mm- and cm-range, typical scattering effects occur. These scattering effect can be compared to the well known effect of ultrasound scattering. Ultrasound gets scattered at regions with different compressibility and density, while photon density waves are scattered at regions with different absorption and scattering coefficient. In this study, analytical solutions for the time dependent photon diffusion equation are used to estimate photon density wave diffraction effects caused by spherical optical inhomogeneities. The detectability of tumors and hemorrhages in the brain, based on the diffraction pattern generated by these heterogeneities, is discussed in detail.

Original language	English (US)
Title of host publication	Photon Transport in Highly Scattering Tissue 1994
Subtitle of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Pages	75-85
Number of pages	11
Volume	2326
DOIs	https://doi.org/10.1117/12.200865
State	Published - Jan 31 1995
Event	Photon Transport in Highly Scattering Tissue 1994 - Lille, France Duration: Sep 6 1994 → Sep 10 1994

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Publisher	SPIE
ISSN (Print)	0277-786X

Conference

Conference	Photon Transport in Highly Scattering Tissue 1994
Country/Territory	France
City	Lille
Period	9/6/94 → 9/10/94

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.200865

Cite this

Hielscher, A. H., Tittel, F. K., & Jacques, S. L. (1995). Imaging in biological tissues by means of diffraction tomography with photon density waves. In Photon Transport in Highly Scattering Tissue 1994: Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2326, pp. 75-85). (Proceedings of SPIE - The International Society for Optical Engineering). https://doi.org/10.1117/12.200865

Imaging in biological tissues by means of diffraction tomography with photon density waves. / Hielscher, Andreas H.; Tittel, Frank K.; Jacques, Steven L.
Photon Transport in Highly Scattering Tissue 1994: Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2326 1995. p. 75-85 (Proceedings of SPIE - The International Society for Optical Engineering).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Hielscher, AH, Tittel, FK & Jacques, SL 1995, Imaging in biological tissues by means of diffraction tomography with photon density waves. in Photon Transport in Highly Scattering Tissue 1994: Proceedings of SPIE - The International Society for Optical Engineering. vol. 2326, Proceedings of SPIE - The International Society for Optical Engineering, pp. 75-85, Photon Transport in Highly Scattering Tissue 1994, Lille, France, 9/6/94. https://doi.org/10.1117/12.200865

Hielscher AH, Tittel FK, Jacques SL. Imaging in biological tissues by means of diffraction tomography with photon density waves. In Photon Transport in Highly Scattering Tissue 1994: Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2326. 1995. p. 75-85. (Proceedings of SPIE - The International Society for Optical Engineering). doi: 10.1117/12.200865

Hielscher, Andreas H. ; Tittel, Frank K. ; Jacques, Steven L. / Imaging in biological tissues by means of diffraction tomography with photon density waves. Photon Transport in Highly Scattering Tissue 1994: Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2326 1995. pp. 75-85 (Proceedings of SPIE - The International Society for Optical Engineering).

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title = "Imaging in biological tissues by means of diffraction tomography with photon density waves",

abstract = "In biological tissues it is possible to generate photon density waves with wavelength below 5 cm. When these kind of waves encounter optical inhomogeneities with diameters in the mm- and cm-range, typical scattering effects occur. These scattering effect can be compared to the well known effect of ultrasound scattering. Ultrasound gets scattered at regions with different compressibility and density, while photon density waves are scattered at regions with different absorption and scattering coefficient. In this study, analytical solutions for the time dependent photon diffusion equation are used to estimate photon density wave diffraction effects caused by spherical optical inhomogeneities. The detectability of tumors and hemorrhages in the brain, based on the diffraction pattern generated by these heterogeneities, is discussed in detail.",

author = "Hielscher, {Andreas H.} and Tittel, {Frank K.} and Jacques, {Steven L.}",

note = "Funding Information: This work was supported in part by the Department of Energy and the Robert A. Welch Foundation. Publisher Copyright: {\textcopyright} 1995 SPIE. All rights reserved.; Photon Transport in Highly Scattering Tissue 1994 ; Conference date: 06-09-1994 Through 10-09-1994",

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AB - In biological tissues it is possible to generate photon density waves with wavelength below 5 cm. When these kind of waves encounter optical inhomogeneities with diameters in the mm- and cm-range, typical scattering effects occur. These scattering effect can be compared to the well known effect of ultrasound scattering. Ultrasound gets scattered at regions with different compressibility and density, while photon density waves are scattered at regions with different absorption and scattering coefficient. In this study, analytical solutions for the time dependent photon diffusion equation are used to estimate photon density wave diffraction effects caused by spherical optical inhomogeneities. The detectability of tumors and hemorrhages in the brain, based on the diffraction pattern generated by these heterogeneities, is discussed in detail.

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Imaging in biological tissues by means of diffraction tomography with photon density waves

Abstract

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