Imaging of hemodynamic effects in arthritic joints with dynamic optical tomography

Andreas H. Hielscher, Joseph M. Lasker, Chris J. Fong, Edward Dwyer

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Optical probing of hemodynamics is often employed in areas such as brain, muscular, and breast-cancer imaging. In these studies an external stimulus is applied and changes in relevant physiological parameters, e.g. oxy or deoxy-hemoglobin concentrations, are determined. In this work we present the first application of this method for characterizing joint diseases, especially effects of rheumatoid arthritis (RA) in the proximal-interphalangeal (PIP) finger joints. Using a dual-wavelength tomographic imaging system together with previously implemented model-based iterative image reconstruction schemes, we have performed dynamic imaging case studies on a limited number of healthy volunteers and patients diagnosed with RA. Inflating a sphygmomanometer cuff placed around the forearm we elicited a controlled vascular response. We observed pronounced differences between the hemodynamic effect occurring in healthy volunteers and patients affected by RA.

Original languageEnglish (US)
Title of host publicationDiffuse Optical Imaging of Tissue
ISBN (Print)0819467731, 9780819467737
StatePublished - 2007
EventDiffuse Optical Imaging of Tissue - Munich, Germany
Duration: Jun 19 2007Jun 21 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceDiffuse Optical Imaging of Tissue


  • Hemodynamics
  • Imaging
  • Optical tomography
  • Rheumatoid arthritis
  • Vascular dynamics

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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