TY - GEN
T1 - Imaging of hemodynamic effects in arthritic joints with dynamic optical tomography
AU - Hielscher, Andreas H.
AU - Lasker, Joseph M.
AU - Fong, Chris J.
AU - Dwyer, Edward
PY - 2007
Y1 - 2007
N2 - Optical probing of hemodynamics is often employed in areas such as brain, muscular, and breast-cancer imaging. In these studies an external stimulus is applied and changes in relevant physiological parameters, e.g. oxy or deoxy-hemoglobin concentrations, are determined. In this work we present the first application of this method for characterizing joint diseases, especially effects of rheumatoid arthritis (RA) in the proximal-interphalangeal (PIP) finger joints. Using a dual-wavelength tomographic imaging system together with previously implemented model-based iterative image reconstruction schemes, we have performed dynamic imaging case studies on a limited number of healthy volunteers and patients diagnosed with RA. Inflating a sphygmomanometer cuff placed around the forearm we elicited a controlled vascular response. We observed pronounced differences between the hemodynamic effect occurring in healthy volunteers and patients affected by RA.
AB - Optical probing of hemodynamics is often employed in areas such as brain, muscular, and breast-cancer imaging. In these studies an external stimulus is applied and changes in relevant physiological parameters, e.g. oxy or deoxy-hemoglobin concentrations, are determined. In this work we present the first application of this method for characterizing joint diseases, especially effects of rheumatoid arthritis (RA) in the proximal-interphalangeal (PIP) finger joints. Using a dual-wavelength tomographic imaging system together with previously implemented model-based iterative image reconstruction schemes, we have performed dynamic imaging case studies on a limited number of healthy volunteers and patients diagnosed with RA. Inflating a sphygmomanometer cuff placed around the forearm we elicited a controlled vascular response. We observed pronounced differences between the hemodynamic effect occurring in healthy volunteers and patients affected by RA.
KW - Hemodynamics
KW - Imaging
KW - Optical tomography
KW - Rheumatoid arthritis
KW - Vascular dynamics
UR - http://www.scopus.com/inward/record.url?scp=36349011875&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36349011875&partnerID=8YFLogxK
U2 - 10.1364/ecbo.2007.6629_22
DO - 10.1364/ecbo.2007.6629_22
M3 - Conference contribution
AN - SCOPUS:36349011875
SN - 0819467731
SN - 9780819467737
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Diffuse Optical Imaging of Tissue
PB - SPIE
T2 - Diffuse Optical Imaging of Tissue
Y2 - 19 June 2007 through 21 June 2007
ER -