TY - JOUR
T1 - Imaging of the lamina cribrosa in glaucoma
T2 - Perspectives of pathogenesis and clinical applications
AU - Kim, Tae Woo
AU - Kagemann, Larry
AU - Girard, Michaël J.A.
AU - Strouthidis, Nicholas G.
AU - Sung, Kyung Rim
AU - Leung, Christopher K.
AU - Schuman, Joel S.
AU - Wollstein, Gadi
N1 - Funding Information:
J.S.S. received royalties for intellectual property licensed by Massachusetts Institute of Technology to Carl Zeiss Meditec. G.W is a consultant for Allergan. This research was supported by National Institutes of Health (NIH) (R01-EY013178 and P30-EY008098) (Bethesda, MD); the Eye and Ear Foundation (Pittsburgh, PA); and unrestricted grants from Research to Prevent Blindness (New York, NY); Imperial College Junior Research Fellowship, Singapore; Ministry of Education, Academic Research Fund, Singapore; UK National Institute for Health Research (NIHR) Biomedical Research Centre based at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology; Basic Science Research Program through the National Research Foundation of Korea (NRF-2011-0013802); National Research Foundation of Korea Grant funded by the Korean Government (2010-0004210). The authors alone are responsible for the content and writing of this article and not necessarily those of the NHS, the NIHR or the UK Department of Health.
PY - 2013/9
Y1 - 2013/9
N2 - The lamina cribrosa (LC) is a sieve-like structure in the sclera where retinal ganglion cell axons exit from the eye. The LC has been known to play a critical role in the pathogenesis of glaucoma. With the advent of imaging technologies, such as enhanced depth imaging, spectral-domain optical coherence tomography (OCT) enables us to unveil the LC in vivo features. The application of adaptive optics technology and a compensatory image-processing algorithm has further improved the visualization of the beams and pores and neural pathways of the LC and the scleral insertion sites. Monitoring the changes of these structures in relation to acute and chronic elevation of intraocular pressure would be germane to decipher the relationship between the stress and strain response of the LC and optic nerve damage and improve our understanding of glaucoma pathophysiology. While the impact of investigating the integrity of LC is substantive, considerable challenges remain for imaging the LC. Nevertheless, with the rapid development of the OCT technology, it is expected that some of these limitations can be overcome and the potentials of LC imaging will be unraveled.
AB - The lamina cribrosa (LC) is a sieve-like structure in the sclera where retinal ganglion cell axons exit from the eye. The LC has been known to play a critical role in the pathogenesis of glaucoma. With the advent of imaging technologies, such as enhanced depth imaging, spectral-domain optical coherence tomography (OCT) enables us to unveil the LC in vivo features. The application of adaptive optics technology and a compensatory image-processing algorithm has further improved the visualization of the beams and pores and neural pathways of the LC and the scleral insertion sites. Monitoring the changes of these structures in relation to acute and chronic elevation of intraocular pressure would be germane to decipher the relationship between the stress and strain response of the LC and optic nerve damage and improve our understanding of glaucoma pathophysiology. While the impact of investigating the integrity of LC is substantive, considerable challenges remain for imaging the LC. Nevertheless, with the rapid development of the OCT technology, it is expected that some of these limitations can be overcome and the potentials of LC imaging will be unraveled.
KW - Glaucoma
KW - Intraocular pressure
KW - Lamina cribrosa
KW - Optical coherence tomography
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U2 - 10.3109/02713683.2013.800888
DO - 10.3109/02713683.2013.800888
M3 - Review article
C2 - 23768229
AN - SCOPUS:84880872076
VL - 38
SP - 903
EP - 909
JO - Current Eye Research
JF - Current Eye Research
SN - 0271-3683
IS - 9
ER -