Immunoisolation of adult porcine islets for the treatment of diabetes mellitus. The use of photopolymerizable polyethylene glycol in the conformal coating of mass-isolated porcine islets

Ronald S. Hill; Greg M. Cruise; Steve R. Hager; Francis V. Lamberti; Xiaojie Yu; Carrie L. Garufis; Yao Yu; Karen E. Mundwiler; John F. Cole; Jeffery A. Hubbell; Orion D. Hegre; David W. Scharp

doi:10.1111/j.1749-6632.1997.tb52208.x

Immunoisolation of adult porcine islets for the treatment of diabetes mellitus. The use of photopolymerizable polyethylene glycol in the conformal coating of mass-isolated porcine islets

Ronald S. Hill, Greg M. Cruise, Steve R. Hager, Francis V. Lamberti, Xiaojie Yu, Carrie L. Garufis, Yao Yu, Karen E. Mundwiler, John F. Cole, Jeffery A. Hubbell, Orion D. Hegre, David W. Scharp

Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Functional porcine islets, free of known pathogens, can serve as a source of insulin producing cells for the treatment of experimentally induced insulin dependent Diabetes Mellitus. Porcine islets can be conformally coated (microencapsulated) with a covalently linked, stable permselective membrane while maintaining islet viability and function. The PEG conformal coating is immunoprotective in a discordant xenograft animal model (porcine islets to rat).

Original language	English (US)
Pages (from-to)	332-343
Number of pages	12
Journal	Annals of the New York Academy of Sciences
Volume	831
DOIs	https://doi.org/10.1111/j.1749-6632.1997.tb52208.x
State	Published - Dec 31 1997

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1111/j.1749-6632.1997.tb52208.x

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Hill, R. S., Cruise, G. M., Hager, S. R., Lamberti, F. V., Yu, X., Garufis, C. L., Yu, Y., Mundwiler, K. E., Cole, J. F., Hubbell, J. A., Hegre, O. D., & Scharp, D. W. (1997). Immunoisolation of adult porcine islets for the treatment of diabetes mellitus. The use of photopolymerizable polyethylene glycol in the conformal coating of mass-isolated porcine islets. Annals of the New York Academy of Sciences, 831, 332-343. https://doi.org/10.1111/j.1749-6632.1997.tb52208.x

Immunoisolation of adult porcine islets for the treatment of diabetes mellitus. The use of photopolymerizable polyethylene glycol in the conformal coating of mass-isolated porcine islets. / Hill, Ronald S.; Cruise, Greg M.; Hager, Steve R. et al.
In: Annals of the New York Academy of Sciences, Vol. 831, 31.12.1997, p. 332-343.

Research output: Contribution to journal › Article › peer-review

Hill, RS, Cruise, GM, Hager, SR, Lamberti, FV, Yu, X, Garufis, CL, Yu, Y, Mundwiler, KE, Cole, JF, Hubbell, JA, Hegre, OD & Scharp, DW 1997, 'Immunoisolation of adult porcine islets for the treatment of diabetes mellitus. The use of photopolymerizable polyethylene glycol in the conformal coating of mass-isolated porcine islets', Annals of the New York Academy of Sciences, vol. 831, pp. 332-343. https://doi.org/10.1111/j.1749-6632.1997.tb52208.x

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abstract = "Functional porcine islets, free of known pathogens, can serve as a source of insulin producing cells for the treatment of experimentally induced insulin dependent Diabetes Mellitus. Porcine islets can be conformally coated (microencapsulated) with a covalently linked, stable permselective membrane while maintaining islet viability and function. The PEG conformal coating is immunoprotective in a discordant xenograft animal model (porcine islets to rat).",

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AU - Lamberti, Francis V.

AU - Yu, Xiaojie

AU - Garufis, Carrie L.

AU - Yu, Yao

AU - Mundwiler, Karen E.

AU - Cole, John F.

AU - Hubbell, Jeffery A.

AU - Hegre, Orion D.

AU - Scharp, David W.

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Immunoisolation of adult porcine islets for the treatment of diabetes mellitus. The use of photopolymerizable polyethylene glycol in the conformal coating of mass-isolated porcine islets

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