Immunolocalization of type X collagen before and after mineralization of human thyroid cartilage

H. Claassen, T. Kirsch

Research output: Contribution to journalArticlepeer-review


In this study the distribution of type X collagen in thyroid cartilages of various ages is described. Fetal and juvenile thyroid cartilage was negative for type X collagen, but showed a strong staining reaction for type II collagen. Type X collagen and calcium deposition were first detected in thyroid cartilage of 18-to 21-year-old adults. Type X collagen was restricted to large chondrocytes near or in mineralized cartilage, confirming the notion that type X collagen precedes mineralization. From these observations it was concluded that chondrocytes in thyroid cartilage undergo differentiation steps that are similar, but much slower, compared to cells in growth plate and sternal cartilage. Some type X collagen-positive areas also showed staining for type I collagen, suggesting that there is a further differentiation of chondrocytes to cells which are characterized by the simultaneous synthesis of type X and I collagen. However, a dedifferentiation process during aging of thyroid cartilage where cells switch from synthesis of type II to type I collagen cannot be excluded.

Original languageEnglish (US)
Pages (from-to)27-32
Number of pages6
Issue number1
StatePublished - Jan 1994

ASJC Scopus subject areas

  • Anatomy
  • General Agricultural and Biological Sciences


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