Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions

Claudia Crescio, Marco Orecchioni, Cécilia Ménard-Moyon, Francesco Sgarrella, Proto Pippia, Roberto Manetti, Alberto Bianco, Lucia Gemma Delogu

Research output: Contribution to journalArticlepeer-review

Abstract

Spaceflights lead to dysregulation of the immune cell functionality affecting the expression of activation markers and cytokine production. Short oxidized multi-walled carbon nanotubes functionalized by 1,3-dipolar cycloaddition have been reported to activate immune cells. In this Communication we have performed surface marker assays and multiplex ELISA on primary monocytes and T cells under microgravity. We have discovered that carbon nanotubes, through their immunostimulatory properties, are able to fight spaceflight immune system dysregulations.

Original languageEnglish (US)
Pages (from-to)9599-9603
Number of pages5
JournalNanoscale
Volume6
Issue number16
DOIs
StatePublished - Aug 21 2014

ASJC Scopus subject areas

  • Materials Science(all)

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