Impact of body mass index, metabolic health and weight change on incident diabetes in a Korean population

Hyun Suk Jung; Yoosoo Chang; Kyung Eun Yun; Chan Won Kim; Eun Suk Choi; Min Jung Kwon; Juhee Cho; Yiyi Zhang; Sanjay Rampal; Di Zhao; Hyun Soo Kim; Hocheol Shin; Eliseo Guallar; Seungho Ryu

doi:10.1002/oby.20751

Impact of body mass index, metabolic health and weight change on incident diabetes in a Korean population

Hyun Suk Jung, Yoosoo Chang, Kyung Eun Yun, Chan Won Kim, Eun Suk Choi, Min Jung Kwon, Juhee Cho, Yiyi Zhang, Sanjay Rampal, Di Zhao, Hyun Soo Kim, Hocheol Shin, Eliseo Guallar, Seungho Ryu

Global Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Objective The aim of this study was to examine an impact of body mass index (BMI) and weight change on the risk of diabetes according to metabolic health status. Methods Cohort study of 34,999 Korean men and women 30-59 years of age free of diabetes at baseline were followed-up annually or biennially for an average of 5.1 years. Being metabolically healthy was defined as not having any metabolic syndrome component. Results During 176,878.6 person-years of follow-up, 889 participants developed diabetes (incidence rate 5.0 per 1000 person-years). Compared to metabolically healthy normal-weight individuals, the adjusted hazard ratios for diabetes in metabolically unhealthy obese and in metabolically healthy obese were 13.7 (95% confidence interval [CI] 9.8-19.0) and 2.7 (95% CI: 1.7-4.3), respectively the aHR (95% CI) for incident diabetes for weight changes of <-0.9, 0.5 to 2.0, and ≥2.1 kg compared to a weight change of -0.9 to 0.4 kg (reference) were 0.80 (0.66-0.97), 0.99 (0.82-1.20), and 1.24 (1.02-1.49), respectively (P-trend<0.001). Conclusions In this large cohort of young and middle age Koreans, metabolic health status, obesity, and weight change were all independently associated with increased incidence of diabetes over 5 years of follow-up.

Original language	English (US)
Pages (from-to)	1880-1887
Number of pages	8
Journal	Obesity
Volume	22
Issue number	8
DOIs	https://doi.org/10.1002/oby.20751
State	Published - Aug 2014

ASJC Scopus subject areas

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Endocrinology
Nutrition and Dietetics

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10.1002/oby.20751

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@article{c6abd4096508418c8d120494cf455b57,

title = "Impact of body mass index, metabolic health and weight change on incident diabetes in a Korean population",

abstract = "Objective The aim of this study was to examine an impact of body mass index (BMI) and weight change on the risk of diabetes according to metabolic health status. Methods Cohort study of 34,999 Korean men and women 30-59 years of age free of diabetes at baseline were followed-up annually or biennially for an average of 5.1 years. Being metabolically healthy was defined as not having any metabolic syndrome component. Results During 176,878.6 person-years of follow-up, 889 participants developed diabetes (incidence rate 5.0 per 1000 person-years). Compared to metabolically healthy normal-weight individuals, the adjusted hazard ratios for diabetes in metabolically unhealthy obese and in metabolically healthy obese were 13.7 (95% confidence interval [CI] 9.8-19.0) and 2.7 (95% CI: 1.7-4.3), respectively the aHR (95% CI) for incident diabetes for weight changes of <-0.9, 0.5 to 2.0, and ≥2.1 kg compared to a weight change of -0.9 to 0.4 kg (reference) were 0.80 (0.66-0.97), 0.99 (0.82-1.20), and 1.24 (1.02-1.49), respectively (P-trend<0.001). Conclusions In this large cohort of young and middle age Koreans, metabolic health status, obesity, and weight change were all independently associated with increased incidence of diabetes over 5 years of follow-up.",

author = "Jung, {Hyun Suk} and Yoosoo Chang and {Eun Yun}, Kyung and Kim, {Chan Won} and Choi, {Eun Suk} and Kwon, {Min Jung} and Juhee Cho and Yiyi Zhang and Sanjay Rampal and Di Zhao and {Soo Kim}, Hyun and Hocheol Shin and Eliseo Guallar and Seungho Ryu",

year = "2014",

month = aug,

doi = "10.1002/oby.20751",

language = "English (US)",

volume = "22",

pages = "1880--1887",

journal = "Obesity",

issn = "1930-7381",

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T1 - Impact of body mass index, metabolic health and weight change on incident diabetes in a Korean population

AU - Jung, Hyun Suk

AU - Chang, Yoosoo

AU - Eun Yun, Kyung

AU - Kim, Chan Won

AU - Choi, Eun Suk

AU - Kwon, Min Jung

AU - Cho, Juhee

AU - Zhang, Yiyi

AU - Rampal, Sanjay

AU - Zhao, Di

AU - Soo Kim, Hyun

AU - Shin, Hocheol

AU - Guallar, Eliseo

AU - Ryu, Seungho

PY - 2014/8

Y1 - 2014/8

N2 - Objective The aim of this study was to examine an impact of body mass index (BMI) and weight change on the risk of diabetes according to metabolic health status. Methods Cohort study of 34,999 Korean men and women 30-59 years of age free of diabetes at baseline were followed-up annually or biennially for an average of 5.1 years. Being metabolically healthy was defined as not having any metabolic syndrome component. Results During 176,878.6 person-years of follow-up, 889 participants developed diabetes (incidence rate 5.0 per 1000 person-years). Compared to metabolically healthy normal-weight individuals, the adjusted hazard ratios for diabetes in metabolically unhealthy obese and in metabolically healthy obese were 13.7 (95% confidence interval [CI] 9.8-19.0) and 2.7 (95% CI: 1.7-4.3), respectively the aHR (95% CI) for incident diabetes for weight changes of <-0.9, 0.5 to 2.0, and ≥2.1 kg compared to a weight change of -0.9 to 0.4 kg (reference) were 0.80 (0.66-0.97), 0.99 (0.82-1.20), and 1.24 (1.02-1.49), respectively (P-trend<0.001). Conclusions In this large cohort of young and middle age Koreans, metabolic health status, obesity, and weight change were all independently associated with increased incidence of diabetes over 5 years of follow-up.

AB - Objective The aim of this study was to examine an impact of body mass index (BMI) and weight change on the risk of diabetes according to metabolic health status. Methods Cohort study of 34,999 Korean men and women 30-59 years of age free of diabetes at baseline were followed-up annually or biennially for an average of 5.1 years. Being metabolically healthy was defined as not having any metabolic syndrome component. Results During 176,878.6 person-years of follow-up, 889 participants developed diabetes (incidence rate 5.0 per 1000 person-years). Compared to metabolically healthy normal-weight individuals, the adjusted hazard ratios for diabetes in metabolically unhealthy obese and in metabolically healthy obese were 13.7 (95% confidence interval [CI] 9.8-19.0) and 2.7 (95% CI: 1.7-4.3), respectively the aHR (95% CI) for incident diabetes for weight changes of <-0.9, 0.5 to 2.0, and ≥2.1 kg compared to a weight change of -0.9 to 0.4 kg (reference) were 0.80 (0.66-0.97), 0.99 (0.82-1.20), and 1.24 (1.02-1.49), respectively (P-trend<0.001). Conclusions In this large cohort of young and middle age Koreans, metabolic health status, obesity, and weight change were all independently associated with increased incidence of diabetes over 5 years of follow-up.

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JO - Obesity

JF - Obesity

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ER -

Impact of body mass index, metabolic health and weight change on incident diabetes in a Korean population

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