Impact of delay after biopsy and post-biopsy haemorrhage on prostate cancer tumour detection using multi-parametric MRI: A multi-reader study

A. B. Rosenkrantz, T. C. Mussi, N. Hindman, R. P. Lim, M. X. Kong, J. S. Babb, J. Melamed, S. S. Taneja

    Research output: Contribution to journalArticle

    Abstract

    Aim: To assess impact of haemorrhage and delay after biopsy on prostate tumour detection using multi-parametric (MP) magnetic resonance imaging (MRI) assessment. Materials and methods: Forty-four patients underwent prostate MRI at 1.5 T using a pelvic phased-array coil, including T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and dynamic contrast-enhanced (DCE) imaging, before prostatectomy. Three radiologists independently reviewed images during four sessions [T2WI, DWI, DCE, and all parameters combined (MP-MRI)] to assess for tumour in each sextant. In a separate session, readers reviewed T1WI to score the extent of haemorrhage per sextant. Accuracy was assessed using logistic regression for correlated data. Results: There was no significant difference in accuracy between readers for any session (p ≥ 0.166), and results were averaged across the three readers for remaining comparisons. Accuracy was significantly greater for MP-MRI than for any parameter alone (p ≤ 0.020). For T2WI alone, there was a trend toward decreased sensitivity in sextants with extensive haemorrhage (p = 0.072). However, accuracy, sensitivity, and specificity were otherwise similar for sextants with and without extensive haemorrhage for all sessions (p = 0.192-0.934). No session showed a significant improvement in accuracy, sensitivity, or specificity in cases with delay after biopsy of over 4 weeks compared with shorter delay. Conclusion: Extensive haemorrhage and short delay after biopsy did not negatively impact accuracy for tumour detection using MP-MRI. Further studies using MP-MRI protocols and interpretation schemes from other institutions are required to confirm these observations.

    Original languageEnglish (US)
    Pages (from-to)e83-e90
    JournalClinical Radiology
    Volume67
    Issue number12
    DOIs
    StatePublished - Dec 2012

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

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    Rosenkrantz, A. B., Mussi, T. C., Hindman, N., Lim, R. P., Kong, M. X., Babb, J. S., Melamed, J., & Taneja, S. S. (2012). Impact of delay after biopsy and post-biopsy haemorrhage on prostate cancer tumour detection using multi-parametric MRI: A multi-reader study. Clinical Radiology, 67(12), e83-e90. https://doi.org/10.1016/j.crad.2012.08.014