Impact of membrane bistability on dynamical response of neuronal populations

Wei Wei, Fred Wolf, Xiao Jing Wang

Research output: Contribution to journalArticle

Abstract

Neurons in many brain areas can develop a pronounced depolarized state of membrane potential (up state) in addition to the normal hyperpolarized state near the resting potential. The influence of the up state on signal encoding, however, is not well investigated. Here we construct a one-dimensional bistable neuron model and calculate the linear dynamical response to noisy oscillatory inputs analytically. We find that with the appearance of an up state, the transmission function is enhanced by the emergence of a local maximum at some optimal frequency and the phase lag relative to the input signal is reduced. We characterize the dependence of the enhancement of frequency response on intrinsic dynamics and on the occupancy of the up state.

Original languageEnglish (US)
Article number032726
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume92
Issue number3
DOIs
StatePublished - Sep 25 2015

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

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