Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary

Joyce Gyamfi, Temitope Ojo, Juliet Iwelunmor, Gbenga Ogedegbe, Nessa Ryan, Amy Diawara, Obiageli Nnodu, Ambroise Wonkam, Charmaine Royal, Emmanuel Peprah

Research output: Contribution to journalComment/debatepeer-review


Background: The burden of sickle cell disease (SCD) is greatest among African nations. Effective scalability of evidence-based interventions (e.g., newborn screening, health education, prophylaxis for infection, optimal nutrition and hydration, hydroxyurea therapy, blood transfusions, and transcranial Doppler (TCD) screening) is urgently needed particularly in these settings for disease management. However, Africa is constrained by limited resources and the lack of capacity to conduct implementation science research for proper understanding of context, and assessment of barriers and facilitators to the uptake and scalability of evidence-based interventions (EBI) for SCD management. Main Body: We outline implementation science approaches to embed EBI for SCD within the African context and highlight key implementation research programs for SCD management. Building implementation research capacity will meet the major need of developing effective life-long and accessible locally-tailored interventions for patients with SCD in Africa. Conclusion: This commentary communicates the importance of the application of implementation science methodology to scale-up evidence-based interventions for the management of SCD in order to reduce pain, prevent other morbidities and premature death experienced by people with SCD in Africa, and improve their overall quality of life.

Original languageEnglish (US)
Article number20
JournalGlobalization and Health
Issue number1
StatePublished - Dec 2021


  • Africa
  • Global health
  • Implementation science research
  • Scale-up
  • Sickle cell disease

ASJC Scopus subject areas

  • Health Policy
  • Public Health, Environmental and Occupational Health


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