In situ forming biodegradable biomaterials

Alison B. Pratt; Jeffrey A. Hubbell

In situ forming biodegradable biomaterials

Alison B. Pratt, Jeffrey A. Hubbell

Chemical and Biomolecular Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

A crosslinking scheme for in situ biomaterial formation was described. It was shown that materials made from pegylated acrylates and multi-cysteine peptides can degraded by enzymatic activity. Materials made from pegylated acrylates and cysteine-containing peptides were used to deliver an active morpho-genetic protein, BMP-2, and to induce bone formation in ectopic implants in rats. It was concluded that the crosslinking reaction is highly self-selective and suitable for forming materials in contact with cells and tissues.

Original language	English (US)
Pages	14
Number of pages	1
State	Published - 2000
Event	Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling - York, United Kingdom Duration: Jul 16 2000 → Jul 19 2000

Conference

Conference	Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling
Country/Territory	United Kingdom
City	York
Period	7/16/00 → 7/19/00

ASJC Scopus subject areas

General Engineering

Cite this

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title = "In situ forming biodegradable biomaterials",

abstract = "A crosslinking scheme for in situ biomaterial formation was described. It was shown that materials made from pegylated acrylates and multi-cysteine peptides can degraded by enzymatic activity. Materials made from pegylated acrylates and cysteine-containing peptides were used to deliver an active morpho-genetic protein, BMP-2, and to induce bone formation in ectopic implants in rats. It was concluded that the crosslinking reaction is highly self-selective and suitable for forming materials in contact with cells and tissues.",

author = "Pratt, {Alison B.} and Hubbell, {Jeffrey A.}",

year = "2000",

language = "English (US)",

pages = "14",

note = "Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling ; Conference date: 16-07-2000 Through 19-07-2000",

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TY - CONF

T1 - In situ forming biodegradable biomaterials

AU - Pratt, Alison B.

AU - Hubbell, Jeffrey A.

PY - 2000

Y1 - 2000

N2 - A crosslinking scheme for in situ biomaterial formation was described. It was shown that materials made from pegylated acrylates and multi-cysteine peptides can degraded by enzymatic activity. Materials made from pegylated acrylates and cysteine-containing peptides were used to deliver an active morpho-genetic protein, BMP-2, and to induce bone formation in ectopic implants in rats. It was concluded that the crosslinking reaction is highly self-selective and suitable for forming materials in contact with cells and tissues.

AB - A crosslinking scheme for in situ biomaterial formation was described. It was shown that materials made from pegylated acrylates and multi-cysteine peptides can degraded by enzymatic activity. Materials made from pegylated acrylates and cysteine-containing peptides were used to deliver an active morpho-genetic protein, BMP-2, and to induce bone formation in ectopic implants in rats. It was concluded that the crosslinking reaction is highly self-selective and suitable for forming materials in contact with cells and tissues.

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M3 - Paper

AN - SCOPUS:18644362535

SP - 14

T2 - Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling

Y2 - 16 July 2000 through 19 July 2000

ER -

In situ forming biodegradable biomaterials

Abstract

Conference

ASJC Scopus subject areas

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