In vitro release of [3H]5-hydroxytryptamine from fetal and maternal brain by drugs of abuse

Kenneth Kramer, Efrain C. Azmitia, Patricia M. Whitaker-Azmitia

Research output: Contribution to journalArticle

Abstract

Cortical synaptosomes were prepared from pregnant dams (GD-17) and rat fetuses (ED-17), loaded with [3H]5-HT and assayed to evaluate release mediated by cocaine (COC), fenfluramine (FEN) and 3,4-methylenedioxymethamphetamine (MDMA). COC and FEN elicited a high-affinity (10-9 M) release response in fetal tissue which was not apparent in the dam. MDMA-induced release was similar in magnitude in both tissue types. Consequently, the release of 5-HT from developing neurons may be one mechanism by which COC and FEN elicit their teratogenetic effects in utero.

Original languageEnglish (US)
Pages (from-to)142-146
Number of pages5
JournalDevelopmental Brain Research
Volume78
Issue number1
DOIs
StatePublished - Mar 18 1994

Keywords

  • 3,4-Methylenedioxymethamphetamine
  • Cocaine
  • Fenfluramine
  • Inhibition
  • Synaptosome
  • Transporter

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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