In vitro susceptibility of mutans streptococci to antimicrobial substances as determined by a membrane transfer assay.

N. K. Childers, P. W. Caufield

Research output: Contribution to journalArticle

Abstract

The in vitro susceptibilities of seven representative strains of mutans streptococci to three topically applied chemotherapeutic agents were determined by a modified membrane transfer assay. The MBCs of chlorhexidine and I2-KI ranged from 0.5 to 1.0%, while SnF2 was sublethal at the highest concentration tested (8%) in all but one strain (AHT; mode MBC, 8.0%). The proposed in vitro assay may be useful for preclinical screening of potential antimicrobial agents prior to use in the oral cavity.

Original languageEnglish (US)
Pages (from-to)153-155
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume34
Issue number1
DOIs
StatePublished - Jan 1990

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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