In vitro susceptibility of mutans streptococci to antimicrobial substances as determined by a membrane transfer assay.

N. K. Childers; P. W. Caufield

doi:10.1128/AAC.34.1.153

In vitro susceptibility of mutans streptococci to antimicrobial substances as determined by a membrane transfer assay.

N. K. Childers, P. W. Caufield

Cariology and Comprehensive Care

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Abstract

The in vitro susceptibilities of seven representative strains of mutans streptococci to three topically applied chemotherapeutic agents were determined by a modified membrane transfer assay. The MBCs of chlorhexidine and I2-KI ranged from 0.5 to 1.0%, while SnF2 was sublethal at the highest concentration tested (8%) in all but one strain (AHT; mode MBC, 8.0%). The proposed in vitro assay may be useful for preclinical screening of potential antimicrobial agents prior to use in the oral cavity.

Original language	English (US)
Pages (from-to)	153-155
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	34
Issue number	1
DOIs	https://doi.org/10.1128/AAC.34.1.153
State	Published - Jan 1990

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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In vitro susceptibility of mutans streptococci to antimicrobial substances as determined by a membrane transfer assay.

Abstract

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